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IRCT201204127327N2 IRCT 2012-05-26 Tabriz University of Medical Sciences Effective comparision of Apotel versus Morphine in reducing of post pure head trauma headache Effective comparision of Apotel versus Morphine in reducing of post pure head trauma headache 2012-05-04 anticipated 60 Complete https://irct.ir/trial/7773 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Traumatic headache. Intervention 1: In intervention group, 1 gr Apotel will be diluted in 100 cc normal saline and be infused in 10 minutes. Intervention 2: In control group, 0.1mg/kg Morphine will be infused. http://anesthpain.com/?page=article&article_id=14903 Background: This randomized, clinical trial evaluates the analgesic and safety of paracetamol and Morphine in management of headache <br /> Objectives: This study aimed to evaluate the analgesic and safety effects of intravenous single dose of paracetamol, versus morphine in post trauma headache in emergency departments.<br /> Patients and Methods: This study was a single-center, prospective, randomized, double-blind clinical trial conducted on two groups treated with intravenous paracetamol and intravenous morphine. Thirty patients were enrolled in each group. Patients (18-55 years-old adults) complaining from headaches due to pure trauma were included in the study. The inclusion criteria required patients to have headachesof more than 40 mm on a 100 mm visual analogue scale without any pathological findings in their clinical examinations and imaging studies.<br /> Results: Mean duration required to treat the headache was 37.43 and 71.93 minutes in the groups administered paracetamol (group A) and morphine (group B), respectively. After 15 minutes of treatment, this changed to 31.7 ± 18.0 mm (95% CI 8.2 to 25.2) and 48.3 ± 14.1 mm (95% CI 8.2 to 25.2) in groups A and B, respectively. Headache of the patients of group A significantly mitigated in comparison with group B (P < 0.005). Headache of group Apatients was significantly mitigated 30 minutes after treatment (P < 0.005).<br /> Conclusions: Intravenous paracetamol is an effective and safe treatment for patients admitted to the emergency department with headaches caused by head trauma.<br /> Keywords: Post Trauma Headache; Paracetamol; Morphine
public Dr Samad shams Vahdati
Golghasht street, Imam reza hospital, Emergency department
Tabriz Iran (Islamic Republic of) +98 41 1335 2078 shams@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr Samad Shams Vahdati
Daneshghah street
Tabriz Iran (Islamic Republic of) +98 41 1335 2078 shamsv@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) All patients with head trauma will be enrolled after obtaining the neourosurgery service examination result that there is no pathologic findings. Patients who have GCS14 or less or are older than 65 or age under 18 years old are excluded 18 years 65 years Both g44.3 Chronic post-traumatic headache Treatment - Drugs Treatment - Drugs In intervention group, 1 gr Apotel will be diluted in 100 cc normal saline and be infused in 10 minutes In control group, 0.1mg/kg Morphine will be infused Headache. Timepoint: one week. Method of measurement: Numeric pain scale. Hypotension. Timepoint: 10min. Method of measurement: Barometer. Hypoxemia. Timepoint: 10 min. Method of measurement: puls oximetry. Tabriz University of Medical Sciences Approved 2012-01-13 Tabriz University of Medical Sciences Ethics Committee Golgasht street Tabriz Iran (Islamic Republic of)