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IRCT20240503061640N1 IRCT 2024-05-20 Combined Military Hospital Post total thyroidectomy hypocalcemia in toxic MNG and effect of post operative intravenous calcium gluconate in its incidence Post total thyroidectomy hypocalcemia in toxic MNG and effect of post operative intravenous calcium gluconate in its incidence 2023-10-15 anticipated 65 Complete https://irct.ir/trial/76800 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: I used computer generated software SPSS version 23 for randomization. First the sample size was randomized into two groups by using SPSS. Then subjects were assign to each group accordingly, Blinding description: Participants were told that they will given post op intravenous calcium gluconate 1 gram 10 ml in 100 ml of infusion as a single dose, or given 10 ml of IV normal saline in 100 ml infusion as a placebo. After informed written consent Patient will be given either medicine post operative. Patient will be told that they will not know which medicine is given to them. As color of both medicine are same, so Patient will not be know which medicine is given. Medicine will be given by resident surgery. 3 Toxic Multinodular goiter and Hypocalcemia. Intervention 1: Intervention group: In this group participants pre operative calcium level will be checked by laboratory calcium testing machine. Then total thyroidectomy will be done for toxic MNG. After surgery patient will be given post operative calcium supplements as single dose intravenous calcium gluconate 1g in 100 ml infusion (in 6 hours). Then post operative calcium levels will be checked after 12, 24 and 48 hours. Intervention 2: Control group: In this group participants pre operative calcium level will be checked by laboratory calcium testing machine. Then total thyroidectomy will be done for toxic MNG. After surgery patient will be given post operative normal saline 10 ml as single dose in 100 ml infusion (in 6 hours). Then post operative calcium levels will be checked after 12, 24 and 48 hours. Yes - There is a plan to make this available What will be shared: POST TOTAL THYROIDECTOMY HYPOCALCEMIA IN TOXIC MNG AND EFFECT OF POST OPERATIVE INTRAVENOUS CALCIUM GLUCONATE IN ITS INCIDENCE When: In January 2025 To whom: Only available for people working in academic institute Conditions: whereisdrahsan@yahoo.com Where to obtain: whereisdrahsan@yahoo.com How to obtain: Through email ID Comments:
public Dr Muhammad Ahsan Mustafa
Bahawalpur cantt
Bahawalpur Pakistan 63100 +92 333 3396180 whereisdrahsan@yahoo.com Combined Military Hospital Bahawalpur scientific Dr Muhammad Ahsan Mustafa
Bahawalpur cantt
Bahawalpur Pakistan 63100 +92 333 3396180 whereisdrahsan@yahoo.com Combined Military Hospital Bahawalpur Pakistan Patient who are with toxic multinodular goiter. Patient who underwent total thyroidectomy. Patient whose pre op calcium level were normal. Pateint who did not have any parathyroid disease. Patient who give consent for study research. no limit no limit Both Patient who are not with toxic multinodular goiter. Patient who have solitary thyroid nodule, hypothyroid, diffuse goiter, thyroid carcinoma and recurrent thyroid swelling. Patient who didn't give consent for study research. Pateint who were not followed. Patient whose pre op calcium were not normal. Patient who were taking pre op calcium supplements. Patient who have parathyroid disease. Pateint who underwent lobectomy and isthmusectomy Patient having any allegy to calcium gluconate. Treatment - Drugs Placebo Intervention group: In this group participants pre operative calcium level will be checked by laboratory calcium testing machine. Then total thyroidectomy will be done for toxic MNG. After surgery patient will be given post operative calcium supplements as single dose intravenous calcium gluconate 1g in 100 ml infusion (in 6 hours). Then post operative calcium levels will be checked after 12, 24 and 48 hours. Control group: In this group participants pre operative calcium level will be checked by laboratory calcium testing machine. Then total thyroidectomy will be done for toxic MNG. After surgery patient will be given post operative normal saline 10 ml as single dose in 100 ml infusion (in 6 hours). Then post operative calcium levels will be checked after 12, 24 and 48 hours. Post total thyroidectomy hypocalcemia. Timepoint: Before and After 12 hours, 24 hours and 48 hour of intervention. Method of measurement: Use laboratory calcium testing machine for measuring calcium level. Combined Military Hospital Approved 2023-09-01 Ethical Committee CMH Bahawalpur CMH Bahawalpur cantt Bahawalpur Punjab Pakistan