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IRCT201401177202N7 IRCT 2014-05-10 Tehran University of Medical Sciences Effects of adding celecoxib on brain-derived neurotrophic factor and on the severity of symptoms in patients with bipolar disorder who receive Electroconvulsive therapy Evaluation and comparison of the effects of celecoxib and placebo on the brain-derived neurotrophic factor and on the severity of mania in patients with bipolar mood disorder in manic phase undergoing electroconvulsive therapy 2011-04-21 anticipated 40 Complete https://irct.ir/trial/7629 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Bipolar Mood Disorder, Manic Episode. Intervention 1: Intervention group: celecoxib 200 mg BID a day before initiation of the elecltoconvulsive therapy until the 6th elecltoconvulsive treatment. Intervention 2: Control group: placebo with similar order as the intervention group and with the same duartion.
public Dr Padideh Ghaeli
Faculty of Pharmacy, Tehran University of Medical Sciences, 16 Azar Street, Tehran
Tehran Iran (Islamic Republic of) +98 21 6695 4709 pghaeli@sina.tums.ac.ir Faculty of Pharmacy, Tehran University of Medical Scienses scientific Dr Padideh Ghaeli
Faculty of Pharmacy, Tehran University of Medical Scienses, 16th Azar Street, Tehran
Tehran Iran (Islamic Republic of) +98 21 6695 2709 pghaeli@sina.tums.ac.ir Faculty of Pharmacy, Tehran University of Medical Scienses Iran (Islamic Republic of) Inclusion criteria: meeting the DSM-IV criteria for manic episode of bipolar mood disorder; age between 17 and 65 years; order of receiving electroconvulsive therapy Exclusion criteria: history of allergy to NSAIDs; lactating and pregnant women, cerebrovascular hemorrhage; severe hepatic or renal disease, Patients with rheumatologic disease, organic brain syndrome, concomitant taking of other NSAIDs or corticosteroids, severe medical conditions like cardiovascular disorders, respiratory and gasterointestinal disease, receiving electroconvulsive therapy in the past 2 months, stroke, presence of contraindication of receiving electroconvulsive therapy 17 years 65 years Both F30 Manic episode Treatment - Drugs Treatment - Drugs Intervention group: celecoxib 200 mg BID a day before initiation of the elecltoconvulsive therapy until the 6th elecltoconvulsive treatment Control group: placebo with similar order as the intervention group and with the same duartion Changes in brain-derived neurotrophic factor. Timepoint: baseline and after sessions 1,3,6 of ECT. Method of measurement: measurment of serum level. Severity of mania. Timepoint: baseline and afterECT 3 and 6. Method of measurement: by Young Mania Rating Scale. Tehran University of Medical Sciences Approved 2010-08-20 Ethics Committee of Tehran University of Medical Sciences Keshvarz Blvd,Tehran University of Medical Sciences Tehran Iran (Islamic Republic of)