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IRCT20240306061184N1 IRCT 2025-04-23 Mazandaran University of Medical Sciences The effect of topical herbal oil based on lavender, Acorus calamus and Turmeric on Taxanes -induced peripheral neuropathy in cancer The effect of topical herbal oil based on lavender, Acorus calamus and Turmeric on Taxanes -induced peripheral neuropathy in cancer patients 2024-07-22 anticipated 74 Complete https://irct.ir/trial/75884 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants are placed in two groups of test and control by block randomization method According to the sample size, we will have 9 blocks of 8 people and 1 block of 2 people. In each block, half of the lottery papers will correspond to "I" or intervention and the rest will be "p" or placebo. The medicine and placebo containers will be identical and they will be identified only based on a code that identifies which medicine and which is placebo, Blinding description: The doctor and the patient are not aware of the type of treatment (placebo or herbal product) assigned either before or after the treatment. In other words, the patient does not know which group he will be placed in and does not know whether the drug he received is the main drug under study or not. On the other hand, the doctor examining the effect of the drug should not be aware of the type of intervention. 3 Taxanes-induced peripheral neuropathy. Intervention 1: Intervention group: In the test group, the participants are asked to apply 1 cc of oil (vegetable) on the surface of the foot (from the ankle to the tip of the toes) and the surface of the hand (from the wrist to the tip of the fingers) three times a day. spread, a total of 6 cc daily. Intervention 2: Control group: In the control group, the participants are asked to apply 1 cc of oil (placebo) on the surface of the foot (from the ankle to the tip of the toes) and the surface of the hand (from the wrist to the tip of the fingers) three times a day. spread, a total of 6 cc daily. Yes - There is a plan to make this available What will be shared: Information on the main outcome and secondary outcome When: 6 months after the publication of the results To whom: Researchers working in academic and scientific institutions Conditions: For research purposes Where to obtain: dr.msadeghi4431@gmail.com Dr. Mehri Sadeghi Khansari How to obtain: A maximum time is one month Comments:
public Mohammad Yosofpoor
Traditional and Complementary Medicine Research Center,Khazar Blvd, next to Baghban Medical Complex (Toubi), Sari, Mazandaran
Sari Iran (Islamic Republic of) ۴۸۱۵۷۳۳۹۷۱ +98 11 3324 4893 m.yousefpour@mazums.ac.ir Mazandaran University of Medical Sciences scientific Mohammad yosofpoor
Traditional and Complementary Medicine Research Center,Khazar Blvd, next to Baghban Medical Complex (Toubi), Sari, Mazandaran
Sari Iran (Islamic Republic of) ۴۸۱۵۷۳۳۹۷۱ +98 11 3324 4893 m.yousefpour@mazums.ac.ir Mazandaran University of Medical Sciences Iran (Islamic Republic of) Patients with breast, gynecological and urology cancer in the age range of 18-80 years with complaints of peripheral neuropathy symptoms, according to the opinion of a neurologist; their neuropathy is due to chemotherapy with taxane drugs. Are undergoing chemotherapy or have a history of chemotherapy, provided that no more than two months have passed since the completion of their chemotherapy, regardless of the number of chemotherapy courses. 18 years 80 years Both Having diabetes and other neuropathies such as Guillain-Barré, multiple sclerosis, and carpal tunnel syndrome Allergy to herbal medicines Stage 4 cancer patients Patients who perform radiotherapy at the same time as chemotherapy G62.0 Drug-induced polyneuropathy Treatment - Drugs Placebo Intervention group: In the test group, the participants are asked to apply 1 cc of oil (vegetable) on the surface of the foot (from the ankle to the tip of the toes) and the surface of the hand (from the wrist to the tip of the fingers) three times a day. spread, a total of 6 cc daily. Control group: In the control group, the participants are asked to apply 1 cc of oil (placebo) on the surface of the foot (from the ankle to the tip of the toes) and the surface of the hand (from the wrist to the tip of the fingers) three times a day. spread, a total of 6 cc daily. Sensory and motor disorders and pain and symptoms of neuropathy in the lower and upper limbs. Timepoint: The beginning of the study (before the start of the intervention) and 28 days after the start of topical herbal oil consumption (the end of the intervention). Method of measurement: To quantitatively evaluate peripheral neuropathy before and after intervention(Questionnaire FACT/GOG-Ntx Version 4)Functional Assessment of Cancer Therapy for patients with neurotoxicity questionnaire - version 4 (FACT-GOG-NTX), Qualitative symptoms of peripheral neuropathy based on the scalePNQ (Patient Neurotoxicity Questionnaire), Pain before and after the intervention; Neuropathic Pain Scale (NPS). Registration of possible complications. Timepoint: While studying. Method of measurement: Side effects registration form. Mazandaran University of Medical Sciences Approved 2024-02-28 Ethics Committee of Mazandaran university of Medical Sciences Traditional and Complementary Medicine Research Center, Khazar Blvd, Sari, Mazandaran Sari Mazandaran Iran (Islamic Republic of)