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IRCT20170114031921N6 IRCT 2024-02-24 Hamedan University of Medical Sciences Evaluating the effect of Doxycycline on biomarkers of oxidative stress in patients with ischemic stroke: a randomized clinical trial study Evaluating the effect of Doxycycline on biomarkers of oxidative stress in patients with ischemic stroke: a randomized clinical trial study 2024-02-29 anticipated 24 Complete https://irct.ir/trial/75559 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: Allocation of patients into two control and intervention groups will be done in a random block. So that there will be 2 sheets A and two sheets B in one envelope, and each time by removing one of the sheets, the patient will be placed in the control or intervention group. The removed sheet will not be returned to the envelope until the sheets inside the envelope are exhausted. Randomization of patients in study groups will be done by a nurse who is not part of the research team, Blinding description: Allocation of patients into two control and intervention groups will be done in a random block. So that there will be 2 sheets A and two sheets B in one envelope, and each time by removing one of the sheets, the patient will be placed in the control or intervention group. The removed sheet will not be returned to the envelope until the sheets inside the envelope are exhausted. Randomization of patients in study groups will be done by a nurse who is not part of the research team. 0 (exploratory trials) Stroke. Intervention group: 100 mg doxycycline every 12 hours for 7 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
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No. 2, Shahid Fahmideh Blvd., Ghaem Ave., Hamadan, Iran
Hamadan Iran (Islamic Republic of) 6517838678 +98 910 679 4733 freshteh_mehri@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Clinical diagnosis of acute hemispheric ischemic stroke Focal neurological disorder MRI and CT radiological findings consistent with the clinical diagnosis of acute hemispheric stroke Absence of other concurrent inflammatory disease no limit no limit Both Available evidence based on acute or chronic intracerebral hemorrhage and cerebral aneurysm Drug intolerance and side effects Z82.3 Family history of stroke Treatment - Drugs Intervention group: 100 mg doxycycline every 12 hours for 7 days Malone dialdehyde. Timepoint: One day before starting doxycycline treatment and 7 days after treatment. Method of measurement: It is checked by using ELISA Reed kits and reading the wavelength by variable spectrophotometer. Hamedan University of Medical Sciences Approved 2022-12-24 Research Ethics Committees of Hamadan University of Medical Scieneces No. 2, Shahid Fahmideh Blvd., Ghaem Ave., Hamadan, Iran Hamadan Hamadan Iran (Islamic Republic of)