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IRCT20240204060903N1 IRCT 2024-02-24 Istanbul Bahçelievler State Hospital, Türkiye Comparison of Sensory and Motor Block Efficacy at Different Reverse Trendelenburg Angles in Patients Undergoing Spinal Anesthesia with Heavy Marcain Comparison of Sensory and Motor Block Efficacy Comparison of Sensory and Motor Block Efficacy at Different Reverse Trendelenburg Angles in Patients Undergoing Spinal Anesthesia with Heavy Marcain 2024-02-10 anticipated 150 Complete https://irct.ir/trial/75398 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Other design features: People will be randomly divided into 6 groups. A study is planned in 150 patients, Randomization description: People will be randomly divided into 6 groups. Working in groups will be done according to the plan according to the selected angle. Patients are randomly divided into groups. While patients are included in the groups, a blind evaluation will be made. 0 (exploratory trials) Istanbul Bahcelievler State Hospital. Intervention 1: Intervention group:Patients in this group will be at 10, 30, 50, 70 and 90 degrees. 10 mg heavy marcain will be administered into the spinal space. Heavy bupivacaine is frequently used in the surgical field for subarachnoid block. While bupivacaine is a 0.5% plain form that does not contain dextrose, the hyperbaric form is the form that occurs with the addition of glucose (80 mg/ml) to plain bubivacaine. The effectiveness of hyperbaric bupivacaine has been studied in many studies, and the sensory block pattern has been observed to be more predictable in hyperbaric bupivacaine than in bupivacaine. Another difference between hyperbaric and plan bupivacaine is the nature and duration of the motor block. Hyperbaric bupivacaine generally has a safer level of effectiveness than bupivacane. In studies, the effectiveness of hyperbaric bupivacaine and other local anesthetic agents has been compared at different doses and in different surgeries, but no study comparing their effectiveness according to different angles in the supine reverse trandelenburg position of the patient has been found in the literature.The standard spinal anesthesia approach in anorectal surgery is performed in a sitting position and frequently with the application of hyperbaric bupivacaine. The applied doses are generally between 5-10 mg. Hyperbaric bupivacaine provides long-term pain relief in the postoperative period. Intervention 2: Control group: Patients in this group will be at 0 degrees. 10 mg heavy marcain will be administered into the spinal space. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Yücel Özgür
Bahçelievler District Saklıvadi Street Ağaoğlu Mycity 30B2 D29
Bahçelievler Turkey 34180 +90 505 524 21 40 anstz@hotmail.com Istanbul Bahçelievler State Hospital scientific Şenel Altun
Bahçelievler District
Bahçelievler Turkey 34180 +90 505 524 21 40 altunsenel@gmail.com Istanbul Bahçelievler State Hospital Turkey ASA (American Society of Anesthesiologists) I-II, 150 patients between the ages of 18-55 who are scheduled for elective anorectal surgery will be included in the study. 18 years 55 years Both Patients who do not want to participate in the study will not be included in the study. Patients who use blood thinners and are pregnant will not be included in the study. Y48.3 Local anaesthetics Treatment - Surgery Treatment - Drugs Intervention group:Patients in this group will be at 10, 30, 50, 70 and 90 degrees. 10 mg heavy marcain will be administered into the spinal space. Heavy bupivacaine is frequently used in the surgical field for subarachnoid block. While bupivacaine is a 0.5% plain form that does not contain dextrose, the hyperbaric form is the form that occurs with the addition of glucose (80 mg/ml) to plain bubivacaine. The effectiveness of hyperbaric bupivacaine has been studied in many studies, and the sensory block pattern has been observed to be more predictable in hyperbaric bupivacaine than in bupivacaine. Another difference between hyperbaric and plan bupivacaine is the nature and duration of the motor block. Hyperbaric bupivacaine generally has a safer level of effectiveness than bupivacane. In studies, the effectiveness of hyperbaric bupivacaine and other local anesthetic agents has been compared at different doses and in different surgeries, but no study comparing their effectiveness according to different angles in the supine reverse trandelenburg position of the patient has been found in the literature.The standard spinal anesthesia approach in anorectal surgery is performed in a sitting position and frequently with the application of hyperbaric bupivacaine. The applied doses are generally between 5-10 mg. Hyperbaric bupivacaine provides long-term pain relief in the postoperative period. Control group: Patients in this group will be at 0 degrees. 10 mg heavy marcain will be administered into the spinal space. As a result of spinal anesthesia, block levels will vary depending on the patient's back angle. Timepoint: Results will be collected from patients within 2 hours. Method of measurement: The level of spinal block will be evaluated by cold test and pinprick test. Istanbul Bahçelievler State Hospital, Türkiye Approved 2023-06-05 Bakırkoy Dr. Sadi Konuk Traınıng And Research Hospıtal| Clınıcal Studıes Ethıcs Commıttee Decısıon Bahçelievler Mah Saklıvadi Sok. Ağaoğlu Mycity 30B2 D29 Bahçelıevler Istanbul Turkey