IRCT20121216011763N61 IRCT 2024-03-05 Esfahan University of Medical Sciences The effect of saffron supplementation on Parkinson's disease Evaluation the effect of saffron supplementation on some indices of inflammation and oxidative stress, stage of disease, motor and non-motor symptoms, mental health, cognitive impairment, intestinal permeability, gastrointestinal symptoms, appetite, fatigue, quality of life, and sleep quality in patients with Parkinson's disease: A triple blind randomized controlled clinical trial 2024-06-21 anticipated 92 Complete https://irct.ir/trial/75378 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients will be done using a four-block randomization method. For this purpose, people will be classified into 4 states based on the variables of gender and stage of the disease and people with the same states will be randomly assigned to intervention and placebo groups in a 1:1 ratio. Block randomization will be done using a list of random numbers generated by the website https://www.sealedenvelope.com/simple and by an independent researcher, Blinding description: This study is a triple blind clinical trial. The saffron supplement and its placebo will be packed identically in terms of (color, shape and smell) in similar boxes. In order to carry out this research in a triple blind manner, patients, researchers who are responsible for interview, sampling and evaluating tests and statistical analyzes will be blinded. 3 Parkinson's disease. Intervention 1: Intervention group: For 12 weeks, daily intake of one tablet containing 100 mg of first-class Sargol saffron prepared by Mojtahedi Company (preparation of tablets will be done at the Faculty of Pharmacy). Intervention 2: Control group: For 12 weeks, daily intake of one tablet containing 100 mg of lactose powder prepared by Pak Azma Company (preparation of the tablets will be done at the Faculty of Pharmacy). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information