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IRCT20240204060896N1 IRCT 2024-02-11 Tehran University of Medical Sciences Effect of isotretinoin on the results of rhinoplasty Comparison of the effects of oral isotretinoin on the results of rhinoplasty (scar and cartilage shape) in patients with thick nasal skin. 2024-02-04 anticipated 40 Complete https://irct.ir/trial/75343 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization is done in a simple way using a table of random numbers using www.randomization.com. The numbers will be placed in closed envelopes, and upon entering, participants will be assigned an envelope and will be placed in one of 2 groups. 3 rhinoplasty. Intervention 1: Intervention group: In this group, from one week before to two months after surgery patients are treated with 20 mg isotretinoin table 3 times a week and the condition of scar and deformation of the nasal cartilage is evaluated 1, 3 and 6 months after consumption. Isotretinoin manufactured in Iran under the brand name NORMSKIN is used in the study. Intervention 2: Control group: In this group, routine drugs are prescribed after surgery and isotretinoin is not prescribed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Subject to the opinion of the supervisor
public Omid Etemad
End of Keshavarz Boulevard
Tehran Iran (Islamic Republic of) 3314114197 +98 21 6119 0000 maryam_nazari1@yahoo.com Tehran University of Medical Sciences scientific Omid Etemd
End of Keshavarz Boulevard
Tehran Iran (Islamic Republic of) 3314114197 +98 21 6119 0000 maryam_nzari1@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Patients with thick nasal skin Patients undergo rhinoplasty for the first time 18 years no limit Both Allergy to vitamin A Pregnancy or intention to become pregnant within the next year and breastfeeding (isotretinoin is contraindicated) Simultaneously suffering from liver, kidney and heart diseases (isotretinoin is contraindicated) Hyperlipidemia (isotretinoin is contraindicated) History of rhinoplasty Skin diseases that change the thickness of the nose, such as rhinophyma M95.0 Acquired deformity of nose Treatment - Other Treatment - Other Intervention group: In this group, from one week before to two months after surgery patients are treated with 20 mg isotretinoin table 3 times a week and the condition of scar and deformation of the nasal cartilage is evaluated 1, 3 and 6 months after consumption. Isotretinoin manufactured in Iran under the brand name NORMSKIN is used in the study. Control group: In this group, routine drugs are prescribed after surgery and isotretinoin is not prescribed. Scars. Timepoint: 1month, 3 months and 6 months after surgery. Method of measurement: The method of variable measurement is qualitative, in the following way, in the follow-up visit after surgery, post-operative photos are taken and compared with preoperative photos by a plastic and reconstructive surgeon. Deformation of nasal cartilage. Timepoint: 1month, 3 months and 6 months after surgery. Method of measurement: The method of variable measurement is qualitative, in the following way, in the follow-up visit after surgery, post-operative photos are taken and compared with preoperative photos by a plastic and reconstructive surgeon. Tehran University of Medical Sciences Approved 2023-10-10 Ethics committee of Tehran University of Medical Science Keshavarz Blvd, Ghods St Tehran Tehran Iran (Islamic Republic of)