IRCT201606237080N4 IRCT 2016-07-04 Vice Chancellor for research of Babol University of Medical Sciences Treatment of abdominal symptoms in non-complicated The effect of mesalazine in comparison with placebo in uncomplicated diverticulosis with abdominal symptoms 2016-06-30 anticipated 120 Complete https://irct.ir/trial/7508 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A diverticulosis. Intervention 1: 3 Pills of mesalazine 500 mg in a day (1.5 gr daily) for 1 week in each month, for 3 months. Intervention 2: 3 pills of placebo, daily, for 1 week in each month, for 3 months.

public Maede Abdinzade

University of Medical Sciences, Ganjafroz Street, Babol

Babol Iran (Islamic Republic of) +98 11 3219 7667 abedinzadeh.ma@yahoo.com Babol University of Medical Sciences scientific Maede Abdinzade

University of Medical Sciences, Ganjafroz Street, Babol

Babol Iran (Islamic Republic of) 4717641367 +98 11 3219 7667 abedinzadeh.ma@yahoo.com Babol University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: the patients between 40 to 70 years old that have chronic abdominal pain and colonoscopy or barium enema are done for them and based on clinical symptoms and colonoscopy and radiology; the diagnosis of diverticulosis is arisen for them. Exclusion criteria: age below 40 and above 70; patients with history of abdominal surgery; musculoskeletal disease; spinal disorders; gallbladder stone; renal stone; bowel motility disease and inflammatory bowel disease. 40 years 70 years Both k57.3, k57 Diverticular disease of intestine, Diverticular disease of large intestine without perforation or abscess, Diverticular disease of both small and large intestine without perforation or abscess, Diverticular disease of intestine, part unspecified, without Treatment - Drugs Treatment - Drugs 3 Pills of mesalazine 500 mg in a day (1.5 gr daily) for 1 week in each month, for 3 months. 3 pills of placebo, daily, for 1 week in each month, for 3 months. Bloat. Timepoint: At the start of intervention, 1 month later, 2 months later, 3 months later. Method of measurement: questionnaire. Mucus discharge. Timepoint: At the start of intervention, 1 month later, 2 months later, 3 months later. Method of measurement: Number of defecation in a week. Constipation. Timepoint: At the start of intervention, 1 month later, 2 months later, 3 months later. Method of measurement: Number of defecation in a week. Abdominal pain. Timepoint: At the start of intervention, 1 month later, 2 months later, 3 months later. Method of measurement: VAS( score 0 to 10). Diverticulitis. Timepoint: At the start of the intervention, after 2 month of treatment. Method of measurement: Clinical symptoms and signs and CT scan. Bleeding. Timepoint: At the start of the intervention, after 2 month of treatment. Method of measurement: See bleeding. Vice Chancellor for research of Babol University of Medical Sciences Approved 2015-09-08 Babol University of Medical Sciences, Deputy of research & technology University of Medical Sciences, Ganjafroz Street, Babol Babol Iran (Islamic Republic of)