]>
IRCT201405227080N2 IRCT 2014-12-05 Vice Chancellor for research of Babol University of Medical Sciences Treatment of chronic and resistant conventional therapy constipation . A comparative study of the effects of pyridostigmine and bisacodyl in Refractory constipation. 2012-06-01 anticipated 70 Complete https://irct.ir/trial/7506 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Constipation. Intervention 1: Intervention group1: 4 weeks use of pyridostigmine( 60mg, Every 8 hours ). Intervention 2: Intervention group 2: 4 weeks use of bisacodyl (5mg, Every 8 hours ).
public Dr Javad Shokri Shirvani
University Sq, Ganje Afrooze Ave
Babol Iran (Islamic Republic of) 4717641367 +98 11 3223 8284 javadshokri@gmail.com Babol University of Medical Sciences scientific Dr Javad Shokri Shirvani
University Sq, Ganje Afrooze Ave
Babol Iran (Islamic Republic of) 4717641367 +98 11 3223 8284 javadshokri@gmail.com Babol University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Patients who have constipation for more than a year and have not responded to conventional treatments . Exclusion criteria: age below 18 and above 75, the underlying disease affecting gastrointestinal motility (eg, hypothyroidism, diabetes and neurological diseases), the use of drugs affecting gastrointestinal motility (eg calcium channel blockers), history of abdominal surgery 18 years 75 years Both K90,K91,K9 Other diseases of the digestive system Treatment - Drugs Treatment - Drugs Intervention group1: 4 weeks use of pyridostigmine( 60mg, Every 8 hours ) Intervention group 2: 4 weeks use of bisacodyl (5mg, Every 8 hours ) The shape of stool. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Based on image measurement. The number of stools per week. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire. Feeling of incomplete defecation. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire. Duration of Defecation per time. Timepoint: At the start of the intervention, Two weeks later, Four weeks later. Method of measurement: Questionnaire. Vice Chancellor for research of Babol University of Medical Sciences Approved 2014-04-22 Ethics Committee Babol University of Medical Sciences University Sq, Ganje Afrooze Ave Babol Iran (Islamic Republic of)