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IRCT20160722029027N14 IRCT 2024-01-31 Shahid Beheshti University of Medical Sciences Investigating the effectiveness of intraovarian injection of platelet rich plasma on ovarian reserve in infertile women due to decreased ovarian reserve Investigating the effectiveness of intraovarian injection of platelet rich plasma on ovarian reserve in infertile women due to decreased ovarian reserve 2024-01-01 anticipated 15 Complete https://irct.ir/trial/75037 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Infertility. Intervention group: In all women included in the study and after collecting background information such as demographic characteristics and records related to previous pregnancy, on the first to third day of menstruation under ultrasound (if there is no follicle above 10 mm and the thickness of the endometrium is below 5 mm and ovulation) and treatment with Pergoveris injectable gonadotropin twice a day, and when the growing follicle reaches 12-14 mm in size, GnRH antagonist (0.25 mg/day cetrotide) will be started subcutaneously. This injection will continue until the day of (ovitrelle (recombinant HCG) (250 micrograms) administration. When the dominant follicle reaches 18 mm, ovulation is induced using (ovitrelle (recombinant HCG (250 micrograms)) and transvaginal oocyte retrieval during 34 to 36 hours after the injection (ovitrelle (recombinant HCG (250 micrograms)) will be performed with ultrasound guidance. On the day of ovulation, after ovarian puncture, 3 cc of PRP injection will be performed. If the IVF cycle fails, on the third Menstrual cycle After checking the serum level of FSH, AMH and the presence of at least one AFC in the ultrasound, the patients are again included in the ovulation stimulation cycle.. Yes - There is a plan to make this available What will be shared: 6 months after the end of the study When: 6 months after the end of the study To whom: 6 months after the end of the study Conditions: 6 months after the end of the study Where to obtain: 6 months after the end of the study - project manager How to obtain: 6 months after the end of the study, she can request from the project manager Comments:
public Leila Nazari
Shahid Beheshti University of Medical Sciences
Tehran Iran (Islamic Republic of) 4631 19395 +98 21 2243 9872 nazari@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Leila Nazari
Shahid Beheshti University of Medical Sciences
Tehran Iran (Islamic Republic of) 4631- 19395 +98 21 2243 9872 nazari@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Women with infertility under 42 years old with diminished ovarian reserve as AMH<1ng/ml or AFC<5 Infertile women with poor ovarian response: with a history of retrieving less than 5 eggs in IVF 18 years 42 years Female Infertility due to inflammation Endometriosis and PID Hyperandrogenism and PCO Anatomical disorder Anatomical disorder Platelet defects bleeding disorders Treatment - Drugs Intervention group: In all women included in the study and after collecting background information such as demographic characteristics and records related to previous pregnancy, on the first to third day of menstruation under ultrasound (if there is no follicle above 10 mm and the thickness of the endometrium is below 5 mm and ovulation) and treatment with Pergoveris injectable gonadotropin twice a day, and when the growing follicle reaches 12-14 mm in size, GnRH antagonist (0.25 mg/day cetrotide) will be started subcutaneously. This injection will continue until the day of (ovitrelle (recombinant HCG) (250 micrograms) administration. When the dominant follicle reaches 18 mm, ovulation is induced using (ovitrelle (recombinant HCG (250 micrograms)) and transvaginal oocyte retrieval during 34 to 36 hours after the injection (ovitrelle (recombinant HCG (250 micrograms)) will be performed with ultrasound guidance. On the day of ovulation, after ovarian puncture, 3 cc of PRP injection will be performed. If the IVF cycle fails, on the third Menstrual cycle After checking the serum level of FSH, AMH and the presence of at least one AFC in the ultrasound, the patients are again included in the ovulation stimulation cycle. Reduced ovarian reserve: AMH serum level<1ng/ml or AFC<5 in women under 42 years of age. Timepoint: 2 months. Method of measurement: In all women included in the study, on the first to third day of menstruation under ultrasound (if there is no follicle above 10 mm and the thickness of the endometrium is below 5 mm and ovulation) and treatment with Pergoveris injectable gonadotropin twice a day, and when the growing follicle reaches 12-14 mm in size, GnRH antagonist (0.25 mg/day cetrotide) will be started subcutaneously. This injection will continue until the day of (ovitrelle (recombinant HCG) (250 micrograms) administration. When the dominant follicle reaches 18 mm, ovulation is induced using (ovitrelle (recombinant HCG (250 micrograms)) and transvaginal oocyte retrieval during 34 to 36 hours after the injection (ovitrelle (recombinant HCG (250 micrograms)) will be performed with ultrasound guidance. On the day of ovulation, after ovarian puncture, 3 cc of PRP injection will be performed. If the IVF cycle fails, on the third Menstrual cycle After checking the serum level of FSH, AMH and the presence of at least one AFC in the ultrasound, the patients are again included in the ovulation stimulation cycle. Shahid Beheshti University of Medical Sciences Approved 2023-12-31 Ethics committee of Shahid Beheshti University of Medical Sciences Ethics committee of Shahid Beheshti University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)