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IRCT20231208060297N1 IRCT 2024-01-28 The university of Lorestan The effects of resistance training, detraining, and retraining on the serum levels of FGF6 and Myod in middle-aged men and women The effects of 12 weeks of resistance training, 24 weeks of detraining, and 24 weeks of retraining on the serum levels of FGF6 and Myod in middle-aged men and women 2023-11-21 anticipated 40 Complete https://irct.ir/trial/74953 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Blinding description: In the current study, only the group that takes blood samples from the subjects and extracts the desired factors in the laboratory, as well as the group that analyzes the extracted data, are kept blind to the study. N/A Examining changes in serum levels of FGF6 and Myod after 12 weeks of resistance training, 24 weeks of non-training and 12 weeks of retraining in middle-aged people. Intervention group: Subjects under the supervision of an experienced trainer participated in a strength training program of three sessions per week for 12 weeks. Each training session consisted of a dynamic warm-up, cool-down phase, and a strength program that lasted approximately 60 minutes. This protocol includes upper body exercises (shoulder press, wide-grip lat pulldown, crunches, chest press, barbell Croul) and lower body (leg press on a 45-degree table, leg press on a 45-degree table, front leg of the machine) with sets and repetitions with progress It was from 2 to 3 and respectively and from 15 to 8 repetitions. The training load intensity was gradually increased from 65% of 1RM to 80% of 1RM. Every four weeks, the 1RM test was repeated for the chest and leg press movements to determine the maximum weight that could be correctly performed in one repetition to evaluate strength changes. After the training period, the subjects are asked to resume their normal physical activities as before the start of the study and not participate in strength training for 24 weeks. A 24-week no-training period is followed by a 12-week retraining phase, using the same resistance training program with starting loads of each exercise appropriate to the physical condition. 48 hours before and after the intervention, blood will be taken from all the subjects and the plasma levels of FGF-6 and MyoD will be checked using the desired kits and by ELISA method.. Yes - There is a plan to make this available What will be shared: After the publication of scientific work, all information can be shared after identifying people When: Looking forward to printing the results To whom: People working in academic institutions and other community members will have access Conditions: Having a research background in the field of the current study and practical use in the field of health for middle-aged and elderly people in society Where to obtain: To receive data, write to the email address: mohsen.yaqoubi@gmail.com How to obtain: Request information only in the form of e-mail and information will be sent as soon as possible Comments:
public MohsenYaghoubi
Unit 3, Vista Building, Gulshan Alley, Mirzai Shirazi Boulevard, Sobhani
Arak Iran (Islamic Republic of) 3815963747 +98 86 3276 0257 mohsen.yaqoubi@gmail.com The university of Lorestan scientific Masoud Rahmati
Central Organization of Lorestan University - Kilometer 5 of Tehran Road - Khoram Abad City - Lorestan Province
Khorramabad Iran (Islamic Republic of) 6815144316 +98 66 3312 0097 masoud2_rahmati@yahoo.com The university of Lorestan Iran (Islamic Republic of) having physical health Willingness to participate in research Failure to perform any type of endurance or strength training in the 12 months prior to the study 30 years 59 years Both Having any type of chronic disease Musculoskeletal injury and joint disorders Use of any type of medicine or supplement Other Intervention group: Subjects under the supervision of an experienced trainer participated in a strength training program of three sessions per week for 12 weeks. Each training session consisted of a dynamic warm-up, cool-down phase, and a strength program that lasted approximately 60 minutes. This protocol includes upper body exercises (shoulder press, wide-grip lat pulldown, crunches, chest press, barbell Croul) and lower body (leg press on a 45-degree table, leg press on a 45-degree table, front leg of the machine) with sets and repetitions with progress It was from 2 to 3 and respectively and from 15 to 8 repetitions. The training load intensity was gradually increased from 65% of 1RM to 80% of 1RM. Every four weeks, the 1RM test was repeated for the chest and leg press movements to determine the maximum weight that could be correctly performed in one repetition to evaluate strength changes. After the training period, the subjects are asked to resume their normal physical activities as before the start of the study and not participate in strength training for 24 weeks. A 24-week no-training period is followed by a 12-week retraining phase, using the same resistance training program with starting loads of each exercise appropriate to the physical condition. 48 hours before and after the intervention, blood will be taken from all the subjects and the plasma levels of FGF-6 and MyoD will be checked using the desired kits and by ELISA method. Increase in serum concentration of FGF6 after 12 weeks of resistance training in middle-aged women and men. Timepoint: At the beginning of the study, 12 weeks after the first intervention, 24 weeks after the second intervention, and 12 weeks after the third intervention. Method of measurement: ELISA kit. Increase in serum concentration of Myod after 12 weeks of resistance training in middle-aged women and men. Timepoint: At the beginning of the study, 12 weeks after the first intervention, 24 weeks after the second intervention, and 12 weeks after the third intervention. Method of measurement: ELISA kit. The university of Lorestan Approved 2023-11-20 The Ethics Committee of Sports Sciences Research Institute (SSRI) Unit 3, Vista Building, Gulshan Alley, Mirzai Shirazi Boulevard, Sobhani Arak Markazi Iran (Islamic Republic of)