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IRCT20200905048620N2 IRCT 2024-02-09 Mazandaran University of Medical Sciences Investigating the effect of kefir drink on gingivitis Comparing the effect of chlorhexidine mouthwash with kefir drink on clinical indices of gingivitis 2024-02-08 anticipated 40 Complete https://irct.ir/trial/74915 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Using random allocation software 2, patients are distributed into two control and intervention groups using the randomized block method (blocks of 4). The numbers of each block are placed in sealed envelopes. Then, according to the order of people's visits, an envelope is opened randomly and numbers are assigned to people. People with even numbers are assigned to the intervention group and people with odd numbers are assigned to the control group. This process is repeated until the last sample is selected. N/A Gingivitis. Intervention 1: Intervention group: This group will be given 100 ml of kefir drink for 21 days. In this study, homemade kefir drink will be used (after boiling 1.5% fat milk of Pegah Dairy Company of Iran and cooling it at room temperature, kefir grains will be It will be added, fermentation will be done at 48°C for 48 hours and then the kefir grains will be separated by filtering) and the patients will be taught to rinse their mouth twice a day for one minute for 3 weeks. Gargle the given. They will also be told to refrain from eating and drinking for half an hour and from consuming other probiotic products during the treatment period. Intervention 2: Control group: This group will be given 0.2% chlorhexidine mouthwash made by Iran Najo Company in the amount of 5 ml per day for 21 days. Patients will be instructed to gargle the given mouthwash for one minute twice a day for 3 weeks. Yes - There is a plan to make this available What will be shared: After finishing the project, the results will be delivered in the form of a final report and electronically (on a CD) to the Research Vice-Chancellor and Faculty of Dentistry of Mazandaran University of Medical Sciences. When: The decision regarding the access to the data will be the responsibility of the vice chancellor of research and the Faculty of Dentistry of Mazandaran Faculty of Medical Sciences, as well as the supervisor. To whom: Vice chancellor of Research, Faculty of Dentistry, Mazandaran University of Medical Sciences and also a supervisor Conditions: To submit the final report and write the article Where to obtain: Vice chancellor of Research, Faculty of Dentistry, Mazandaran University of Medical Sciences and also a supervisor How to obtain: Written request to the research assistant or the school of Dentistry of Mazandaran University of Medical Sciences and obtaining the consent of the supervisor Comments:
public Leila Jabbareh
Sari Dental clinic., next to Touba .,Caspian Square
Sari Iran (Islamic Republic of) 33971-48157 +98 11 3329 1895 l.jabbareh@mazums.ac.ir Mazandaran University of Medical Sciences scientific Dr.Leila Jabareh
Sari Dental Clinic., next to Touba ., Caspian Square
Sari Iran (Islamic Republic of) 33971-48157 +98 11 3329 1895 l.jabbareh@mazums.ac.ir Mazandaran University of Medical Sciences Iran (Islamic Republic of) Patients who have appropriate cooperation Patients with at least 20 functioning teeth Patients with plaque-related gingivitis 18 years no limit Both People with systemic diseases People using corticosteroids and smoking People who are allergic to mouthwash Poorly cooperative people People have orthodontics and prostheses Pregnant people People with a history of antibiotic treatment or taking anti-inflammatory drugs in the last 3 months People with mouth breathing habit K05.10 Chronic gingivitis, plaque induced Prevention Prevention Intervention group: This group will be given 100 ml of kefir drink for 21 days. In this study, homemade kefir drink will be used (after boiling 1.5% fat milk of Pegah Dairy Company of Iran and cooling it at room temperature, kefir grains will be It will be added, fermentation will be done at 48°C for 48 hours and then the kefir grains will be separated by filtering) and the patients will be taught to rinse their mouth twice a day for one minute for 3 weeks. Gargle the given. They will also be told to refrain from eating and drinking for half an hour and from consuming other probiotic products during the treatment period. Control group: This group will be given 0.2% chlorhexidine mouthwash made by Iran Najo Company in the amount of 5 ml per day for 21 days. Patients will be instructed to gargle the given mouthwash for one minute twice a day for 3 weeks. Dental plaque index. Timepoint: At the beginning of the study (before using mouthwashes) and 7 and 21 days after starting to use mouthwashes. Method of measurement: Observing and recording the plaque index of each tooth according to the Loe & Silness scale table. Gingival index. Timepoint: At the beginning of the study (before using mouthwashes) and 7, 21 days after starting to use mouthwashes. Method of measurement: Examination and recording of gingival index for each tooth according to Loe & Silness scale table for gingival index. Gingival sulcus bleeding index. Timepoint: At the beginning of the study (before using mouthwashes) and 7, 21 days after starting to use mouthwashes. Method of measurement: Examination and recording of gingival bleeding for each tooth by periodontal probe and Muhlemann & Son table. Mazandaran University of Medical Sciences Approved 2024-01-09 Ethics Committee of Mazandaran University of Medical Sciences Research Vice-Chancellor ., University Building No. 2., Moalem Square., Sari Mazandaran Iran (Islamic Republic of)