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IRCT20240109060657N1 IRCT 2024-02-12 Boushehr University of Medical Sciences The effect of two methods of using dexamethasone in reducing pain after root canal treatment Investigating the effect of dexamethasone as the final rinse inside the root canal compared to infiltration injection after the end of treatment in reducing pain after root canal treatment in patients with irreversible pulpitis. 2024-02-14 anticipated 96 Complete https://irct.ir/trial/74913 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are assigned to three treatment groups A, B, C using the method of random blocks (Balance block randomization), the size of each block is 6 and the total number of blocks is 16 as described in the attached table. Randomization was done using the free database "https://www.sealedenvelope.com/" with Seed=127686074750462. Therefore, in a randomized controlled clinical trial study, 32 patients in each group included local injection of dexamethasone (group A), final washing inside the canal with dexamethasone (group B) and no use of dexamethasone (group C) in reducing pain after molar root treatment. was included in the study in parallel, Blinding description: In this research, the patients are unaware of the intervention group in which they are placed. Root canal treatment in patients is performed by the therapist (root canal treatment specialist) and the evaluation is done by the student who is unaware of the type of treatment intervention. 3 Irreversible pulpitis. Intervention 1: Intervention group 1: dexamethasone infiltration injection; After the end of the root treatment, a carpool (2 ml) of dexamethasone containing 8 mg of dexamethasone phosphate (as disodium salt) from Darou pakhsh company is infiltrated on the buccal side of the tooth. Intervention 2: Intervention group 2: final washing inside the canal with dexamethasone; After the preparation of the root canal and before filling the canal, the canal is washed with dexamethasone from Darou Pakhsh Company, and then the canal is dried and obturated. Intervention 3: Control group: not using dexamethasone; The patient does not receive any intervention with dexamethasone during root canal treatment. Yes - There is a plan to make this available What will be shared: Average amount of pain after treatment recorded by patients in all three groups and analysis of their results When: Beginning of the access period from 2024 to 2027 To whom: The general public Conditions: There are no special conditions. Where to obtain: Mohammad Sarlak Email: msarlak269@gmail.com Phone: 09184900295 How to obtain: Send a request to a phone number or email Comments:
public mina seyed habashi
Moallem Blvd
Bushehr Iran (Islamic Republic of) 7514633341 +98 77 3332 2081 mina.s.habashi.64@gmail.com Boushehr University of Medical Sciences scientific Mina Seyed Habashi
Moallem blvd
Bushehr Iran (Islamic Republic of) 7514633341 +98 77 3332 2081 mina.s.habashi.64@gmail.com Boushehr University of Medical Sciences Iran (Islamic Republic of) Male and female patients Age over 18 years old Vital pulp with a diagnosis of symptomatic or asymptomatic pulpitis None of systemic diabetes and cardiovascular diseases and allergic problems Willingness to cooperate One-session root canal treatment The possibility of achieving patency in all canals in preoperative radiography Absence of periodontal problems 18 years no limit Both The complexity of the treatment and the possibility of prolonging the treatment time for more than 2 hours, which can be estimated from the patient's radiograph before starting the treatment. History of gastric ulcer or gastrointestinal bleeding History of allergy to NSAIDs or corticosteroids Risk of renal failure or renal damage K04.0 Pulpitis Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: dexamethasone infiltration injection; After the end of the root treatment, a carpool (2 ml) of dexamethasone containing 8 mg of dexamethasone phosphate (as disodium salt) from Darou pakhsh company is infiltrated on the buccal side of the tooth. Intervention group 2: final washing inside the canal with dexamethasone; After the preparation of the root canal and before filling the canal, the canal is washed with dexamethasone from Darou Pakhsh Company, and then the canal is dried and obturated. Control group: not using dexamethasone; The patient does not receive any intervention with dexamethasone during root canal treatment. Average pain intensity. Timepoint: in the times before intervention, 3 hours after treatment, 6 hours, 12 hours, 24 hours after treatment. Method of measurement: NPRS ( Numeric Pain Rating Scale). Boushehr University of Medical Sciences Approved 2023-08-26 Ethics committee of Bushehr University of Medical Sciences Moallem blvd Bushehr Boushehr Iran (Islamic Republic of)