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IRCT20231127060200N1 IRCT 2024-03-04 Rafsanjan University of Medical Sciences evaluation of Probiotic lozenges, fluoride Mouthwash and Xylitol gum on Streptococcus mutans Comparative evaluation of Probiotic lozenges tablets with Mouthwash containing fluoride and cetyl pyridinium chloride and chewing gum containing Xylitol on oral Streptococcus mutans coloni 2024-04-02 anticipated 72 Complete https://irct.ir/trial/74675 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: People will be divided into 3 equal groups using random permutation block method. In this study, blocks of 9 will be used in such a way that three cards will be prepared for each group (9 cards in total) and letters A, B and C will be written on the cards, which represent the first, second and third groups. Then, when the first person enters the study, one of the 9 selection cards will be randomly selected and the person will be placed in the same group. When the second person enters, one of the remaining 8 selection cards will be selected and the person will be placed in the specified group. The process will be repeated until all 9 cards are selected (first block) and people 10 to 18 who are the second block will be placed in three groups (three people in each group) like the first block, and this process will be repeated up to 72 people. By using this method, in addition to randomly placing people in groups, the number in the three groups will be exactly equal. N/A Dental caries. Intervention 1: The first intervention group: they will receive one lactogam lozenge daily (a product of Lactogam Company (Tehran-Iran)) immediately after brushing their teeth, and they will be asked to continue sucking the lozenge for about half an hour and avoid swallowing it quickly. They are asked not to eat, drink or have a snack for half an hour after taking the pill. Intervention 2: The second intervention group: this group is asked to keep 15 mg of mouthwash (Vivaan alcohol-free General mouthwash produced by Rogin Company (Tabriz-Iran)) twice a day (after breakfast and before bed after brushing teeth) for 60 seconds. and avoid eating and drinking for at least half an hour afterwards. Intervention 3: The third intervention group: This group is asked to consume Miradent xylitol gum (Hager pharma-Disburg-Germany), consume four pieces of gum daily after breakfast, lunch, snack and dinner and continue chewing it for at least 5 minutes. . No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Ali Nabavizade
Dental school, Khalij-e fars Blvd.
Rafsanjan Iran (Islamic Republic of) 7717931136 +98 34 3428 0031 alinabavizadeh@gmail.com Rafsanjan University of Medical Sciences scientific Ali Nabavizade
Khalij-e fars Blvd. Dentistry Faculty
Rafsanjan Iran (Islamic Republic of) 7717931136 +98 34 3424 2322 alinabavizadeh@gmail.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Proper oral hygiene (brush at least twice a day) The presence of at least 6 healthy teeth in each jaw without caries or complex restorations and crowns 18 years 30 years Both Suffering from any systemic disease Use of any type of antibiotic and probiotic products during the last month Fluoride therapy and use of fluoride or antibacterial mouthwash during the last two weeks Using birth control pills and being pregnant Use of orthodontic devices and brackets, fixed and mobile prosthesis Presence of sensitivity to probiotic products or other elements in the study such as fluoride or xylitol Suffering from rapidly progressive caries, acute periodontal and gum diseases. smoking Prevention Prevention Prevention The first intervention group: they will receive one lactogam lozenge daily (a product of Lactogam Company (Tehran-Iran)) immediately after brushing their teeth, and they will be asked to continue sucking the lozenge for about half an hour and avoid swallowing it quickly. They are asked not to eat, drink or have a snack for half an hour after taking the pill. The second intervention group: this group is asked to keep 15 mg of mouthwash (Vivaan alcohol-free General mouthwash produced by Rogin Company (Tabriz-Iran)) twice a day (after breakfast and before bed after brushing teeth) for 60 seconds. and avoid eating and drinking for at least half an hour afterwards. The third intervention group: This group is asked to consume Miradent xylitol gum (Hager pharma-Disburg-Germany), consume four pieces of gum daily after breakfast, lunch, snack and dinner and continue chewing it for at least 5 minutes. . The average number of Streptococcus mutans colonies. Timepoint: Sampling of patients will be done before the intervention and also on the 2nd, 14th and 30th days after the intervention. Method of measurement: Sampling of saliva by non-stimulating method and culture. Rafsanjan University of Medical Sciences Approved 2022-12-07 Ethics committee of Rafsanjan University of Medical Sciences Rafsanjan - Imam Ali Boulevard - Central Organization Rafsanjan Kerman Iran (Islamic Republic of)