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IRCT20231226060526N1 IRCT 2024-02-13 Sanandaj University of Medical Sciences Investigating the effect of dexamethasone injection in the first 24 hours in preventing kidney scaring in children with pyelonephritis Investigating the effect of dexamethasone injection in the first 24 hours in preventing kidney scaring in children with pyelonephritis 2024-02-20 anticipated 100 Complete https://irct.ir/trial/74614 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The sample size was calculated based on the study of Liviana Da Dalt et al., which had 42 people in each group and assumed a 20% difference in scar formation in the two groups (in other words, a 20% reduction in scar formation in the group receiving dexamethasone) and with the following assumptions: 49 people were obtained in each group, and to increase the accuracy of the study, 50 people in each group and a total of 100 people are included in this study. Children according to the row of the list in such a way that children with even rows will be placed in group A and children with odd rows will be placed in group B. Double blocks (AB) will be formed, Blinding description: After the grouping, the patient care team will inject drugs and placebos to the patients of the designated groups according to the instructions, and the researcher and the patient will not be informed about the status of the grouping and the type of drug prescribed in the group. 3 Acute pyelonephritis. Control group: They will receive only routine care. Yes - There is a plan to make this available What will be shared: The data file will be shareable after the approval of the research vice-chancellor of the faculty. When: The access period starts 6 months after the results are published To whom: Researchers working in academic and scientific institutions Conditions: There is no specific case. Where to obtain: ziahejazi1933@gmail.com How to obtain: After receiving the application, the application will be submitted to the research vice-chancellor of the university, and if approved, the necessary information will be sent via email. Comments:
public Seyyed Zia Hijazi
Keshavarz Street
Sanandaj Iran (Islamic Republic of) 6617713446 +98 87 6664 6580 szhejazi1402@gmail.com Sanandaj University of Medical Sciences scientific Seyed Zia Hejazi
Keshavarz Street
Sanandaj Iran (Islamic Republic of) 6619667761 +98 87 3328 5912 szhejazi1402@gmail.com Sanandaj University of Medical Sciences Iran (Islamic Republic of) Children from 1 month to 12 years with first episode of fever T > 38°C having a urinary tract infection and a positive urine culture The presence of a positive urine culture, which according to the definition includes at least 100000 CFUs/mL from a clean sample obtained with a urine bag, or at least 10000 CFUs/mL from a sample obtained by catheterization, or the growth of any amount of bacteria from a sample obtained by suprapubic aspiration. 1 year 12 years Both Endocrine disease Immunosuppressive therapy Known cancer or uropathy Those who had an abnormal DMSA before late assessment (at least 6 months follow-up) had a second UTI. N13.7 Vesicoureteral-reflux Treatment - Drugs Control group: They will receive only routine care Primary outcome of presence of renal scar in Dimercaptosuccinic acid renal scan. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan. The presence of kidney scar in children groups A and B with higher Procalcitonin and the acceptability of steroid adjuvant in terms of the amount of treatment and side effects. Timepoint: 6-month follow-up. Method of measurement: Dimercaptosuccinic acid (DMSA) renal scan. Sanandaj University of Medical Sciences Approved 2023-08-22 Ethics committee of Kurdistan University of Medical Sciences Pasdaran Street Sanandaj Kurdistan Iran (Islamic Republic of)