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IRCT20231223060507N1 IRCT 2024-01-15 Shiraz University of Medical Sciences Comparison of midodrine with L -carnitine in the treatment of intradialytic hypotension Comparison of midodrine with L -carnitine in the treatment of intradialytic hypotension 2024-01-05 anticipated 30 Complete https://irct.ir/trial/74611 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Eligible participants were allocated to the midodrine or L-carnitine group in a 1:1 ratio. A blocked randomization sequence with block sizes of 4, 6, and 10 was generated using the Sealed Envelope online randomization tool, Blinding description: The study is one-sided blind. Patients do not know how the drug is allocated and do not know which group they belong to. The drug allocator does not know about the placement of people in two groups. 3 End Stage Renal Diesease. Intervention 1: Intervention group: A group of patient is given midodrine 5 mg a half hours before dialysis for one month. Intervention 2: Intervention group: The second group of patients is given oral L-carnitine 1000 mg 30-60 min before dialysis for one month. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals. When: The access period starts 6 months after the results are published. To whom: Public use Conditions: There is no obstacle to using the data by mentioning the source. Where to obtain: Shiraz university of medical sciences How to obtain: The request for data should be made through the university website. Comments:
public Dr Fatemeh Rohani
Internal Medicine Group office , Namazi Hospital
Shiraz Iran (Islamic Republic of) 7193613311 +98 71 3647 4332 drfatemehrohani@sums.ac.ir Shiraz University of Medical Sciences scientific Dr Fatemeh Rohani
Internal Medicine Group office , Namazi Hospital
Shiraz Iran (Islamic Republic of) 7193613311 +98 71 3647 4332 drfatemehrohani@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Dialysis patients of Namazi and Shahid Faqihi hospitals At least two months have passed since they started dialysis Dialyze at least twice a week In more than 50% of dialysis sessions, intradialytic hypotension according to the variable definition of the plan 18 years no limit Both Intradialytic hypotension may be due to other reasons such as sepsis, untreated active cancer, heart failure... N18.5 Chronic kidney disease, stage 5 Treatment - Drugs Treatment - Drugs Intervention group: A group of patient is given midodrine 5 mg a half hours before dialysis for one month Intervention group: The second group of patients is given oral L-carnitine 1000 mg 30-60 min before dialysis for one month. The amount of blood pressure drop during hemodialysis. Timepoint: Blood pressure was assessed immediately before and within 5 minutes after each hemodialysis session during the one-month treatment period. Method of measurement: Mercury sphygmomanometer. Shiraz University of Medical Sciences Approved 2023-12-26 Ethics committee of Shiraz University of Medical Sciences Shiraz University of Medical Sciences, Zand Street Shiraz Fars Iran (Islamic Republic of)