IRCT20161212031362N4 IRCT 2024-05-10 Iranian Center of Neurological Research Evaluating the short-term effect of Fampridine on cognitive function in Multiple sclerosis patients Assessing the effect of Fampridine on cognitive outcome measures in multiple sclerosis patients: A double-blind, randomized, placebo-controlled study 2024-05-19 anticipated 108 Complete https://irct.ir/trial/74578 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of the study is achieved by block randomization of patients in to blocks of 12 (6 in Fampridine group and 6 in Placebo group) by Web-based Randomization. each space in any given block is given a code consisting of 3 random digits or letters (fk8 for example). These codes are written on the drug labels as well and are given to patients enrolled in the study. The study coordinators will use a list containing the order of these codes, and according to this list and in sequence of entry into the study, they will deliver the vial to the participants, Blinding description: Study participants and other health care providers, including medical staff involved in the study, are blinded to the allocation of patients into either the Fampridine or placebo group. Medications and placebos are administered to patients by a clinical observer who remains unaware of the contents of the medication vials. 3 Multiple sclerosis. Intervention 1: Control group: Patients are given Placebo tablet for 12 weeks which is identical in shape and other physical characteristics as well as packaging. Drugs are instructed to be used every 12 hours, similar to the intervention group. Patients are instructed to take the tablet without food, on an empty stomach. Intervention 2: Intervention group: Patients are given Fampridine 10mg (Dalphyra, Cinnagen) for 12 weeks (instructed to be taken every 12 hours one in the morning and one in the afternoon). Patients are instructed to take the tablet without food, on an empty stomach. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information