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IRCT20230823059227N2 IRCT 2024-07-30 Karaj University of Medical Sciences Effect of magnesium sulfate on reducing the duration and pain of labor Intravaginal Magnesium Sulfate vs Intravenous Dexamethasone for Labor Acceleration: A Bayesian Adaptive Randomized Controlled Trial 2024-08-21 anticipated 150 Complete https://irct.ir/trial/74207 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: After the eligibility of the patient was recognized and written informed consent was obtained, the patients were randomly assigned to one of the three intervention (magnesium sulfate) and comparison (intravenous dexamethasone) and control ( routine treatment) will be allocated. A randomization list is prepared. To prepare the randomization list, from the web-based software to the address https://www.sealedenvelope.com/simple-randomiser/v1/lists will be used, Blinding description: It is not possible to blind the patient. The researcher investigating the outcome and analyzing the data: He is not aware of the patient's randomization group and he is the only researcher who randomly selected the list. He is aware of this matter. 3 Prolonged first stage (of labor). Intervention 1: The intravenous dexamethasone group. 50 people in the intravenous dexamethasone group (8 mg or 2 cc of intravenous dexamethasone diluted with distilled water and injected intravenously during the active phase of slow labor) . Intervention 2: Vaginal magnesium sulfate group. 50 people in the vaginal magnesium sulfate group (10 cc of 50% magnesium sulfate, which is poured directly on the client's cervix during the active phase of labor. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Kobra Hosseini
Alborz University of Medical Science, Official settlement, North Taleghani boulevard, Taleghani Square, Karaj, Alborz Province
Karaj Iran (Islamic Republic of) 3194673761 +98 26 3434 9590 Kobra.hosseini1990@gmail.com Karaj University of Medical Sciences scientific Kobra Hosseini
Alborz University of Medical Science, Official settlement, North Taleghani boulevard, Taleghani Square, Karaj, Alborz Province
Karaj Iran (Islamic Republic of) 3194673761 +98 26 3434 9590 Kobra.hosseini1990@gmail.com Karaj University of Medical Sciences Iran (Islamic Republic of) Pregnant woman candidate for vaginal birth Low risk of pregnancy Live singleton fetus Gestational age of 38 weeks and above Bishop score less than 4 18 years 40 years Female History of infertility Having dangerous underlying diseases failure to progress bradycardia History of uterine scar O63.0 Prolonged first stage (of labor) Treatment - Drugs Treatment - Drugs The intravenous dexamethasone group. 50 people in the intravenous dexamethasone group (8 mg or 2 cc of intravenous dexamethasone diluted with distilled water and injected intravenously during the active phase of slow labor) . Vaginal magnesium sulfate group. 50 people in the vaginal magnesium sulfate group (10 cc of 50% magnesium sulfate, which is poured directly on the client's cervix during the active phase of labor Duration of labor. Timepoint: After delivery. Method of measurement: Stopwatch. Bishop Score changes. Timepoint: Every two hours until delivery. Method of measurement: Score Bishop Curve. Changes in neonatal blood glucose level. Timepoint: The first 2 hours after delivery. Method of measurement: Newborn blood sugar measurement with a glucometer in the first 2 hours after delivery. Karaj University of Medical Sciences Approved 2024-06-08 Ethics committee of Alborz University of Medical Science Alborz University of Medical Science, Official settlement, North Taleghani boulevard, Taleghani Square, Karaj, Alborz Province Karaj Alborz Iran (Islamic Republic of)