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IRCT201202026958N3 IRCT 2012-06-07 Lorestan University of Medical Sciences Evaluation of aspirin resistance in different doses of aspirin Evaluation of aspirin resistance in different doses of ASA by bleeding time 2012-07-01 anticipated 370 Complete https://irct.ir/trial/7413 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Diagnostic. N/A Aspirin resistance. Intervention 1: Testing group1: aspirin (80 mg) , 1 pill per day. Intervention 2: Testing group 2: aspirin (81mg), 1 pill per day. Intervention 3: Testing group3: aspirin (100 mg), 1 pill per day. Intervention 4: Testing group4: aspirin (325 mg), 1 pill per day. Intervention 5: Control group : placebo, 1 pill per day.
public Dr Ali Maleki
N15, Ostad Davami 4 , Shahid Beheshti Street
Broujerd Iran (Islamic Republic of) 6916726611 +98 66 2353 8057 maleki.a@lums.ac.ir dralimaleki@yahoo.com Lorestan University of Medical Sciences scientific Dr Ali Maleki
N15, Ostad Davami4 , Shahid Beheshti Street
Broujerd Iran (Islamic Republic of) 6916716611 +98 66 2353 8057 dralimaleki@yahoo.com maleki.a@lums.ac.ir Lorestan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: All participants 35 years old and older , who are living in Borujerd city.Participants should have used ASA at least for 5 days. Exclusion criteria: History of acquired or congenital coagulation disorders ,chronic kidney diseases and blood discrasia were excluded from the study. Consumption of some medications such as other platelet inhibitors and anticoagulants such as warfarin ; and volunteers with platelet count less than 150000. 35 years 149 years Both Y45.1 Salicylates Diagnosis Diagnosis Diagnosis Diagnosis Diagnosis Testing group1: aspirin (80 mg) , 1 pill per day Testing group 2: aspirin (81mg), 1 pill per day Testing group3: aspirin (100 mg), 1 pill per day Testing group4: aspirin (325 mg), 1 pill per day Control group : placebo, 1 pill per day Bleeding time and urinary thromboxane B2. Timepoint: Once , after intervention. Method of measurement: IVY method. Thromboxane B2. Timepoint: Once after intervention. Method of measurement: Urinary sample. Lorestan University of Medical Sciences Approved 2012-01-31 Lorestan University of Medical Sienceses Kamalvand Research Center Khoramabad Iran (Islamic Republic of)