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IRCT20231030059908N2 IRCT 2023-12-25 Islamic Azad University Herbix compound In The Facial Herpes. Investigation Of The Effect Of Herbix compound In The Treatment Of Facial Herpes. 2024-01-21 anticipated 15 Complete https://irct.ir/trial/74110 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: .In this study, the clinical caregivers of this doctor and her assistants. 1-2 herpes simplex. Intervention 1: Intervention group: In addition to the standard treatment for Herpes Simplex, this group receives a new drug called Herbix. Intervention 2: Control group:They receive only the standard drug, acyclovir. Intervention 3: Intervention group: Intervention group: After confirming the effect of Herbex drug, this time patients will only receive Herbix drug. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is More time is needed to make a decision
public Gholamreza Keramatiyan
48, Abdulmutallab, Shahid Qorani Blvd, Mashhad Town
Mashhad Iran (Islamic Republic of) 9196664944 0098513529717 keramatiyanGH1@gmail.com Islamic Azad University scientific Mohamadreza KHakzad
Rezashahr, No. 83, Daabel Khazai 2, Mashhad Town
Mashhad Iran (Islamic Republic of) 9177773435 +98 51 3225 0041 MR.khakzad@gmail.com Islamic Azad University Iran (Islamic Republic of) Clinical symptoms of herpes such as tingling and itching around the wound. Small blisters filled with liquid on the skin of the face. Scaling of small merged blisters. Fluid secretion. no limit no limit Both Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: In addition to the standard treatment for Herpes Simplex, this group receives a new drug called Herbix Control group:They receive only the standard drug, acyclovir Intervention group: Intervention group: After confirming the effect of Herbex drug, this time patients will only receive Herbix drug. RNA extraction. Timepoint: At the beginning of the study, on the thirtieth day. Method of measurement: HDF fibroblast cell, 8-OH-dG, HSV-1 gene, caspase-3 gene, caspase-9 gene, Anti-Herpe. Real-time Polymerase chain reaction investigation. Timepoint: At the beginning of the study, on the thirtieth day. Method of measurement: Commercial kit of Ben Yakhte company. Antiviral antibody level in serum. Timepoint: At the beginning of the study, on the thirtieth day. Method of measurement: ELISA technique and abCAM company kit. DNA damage. Timepoint: The beginning of the study. Method of measurement: 8-OH-dG level in culture supernatant. Islamic Azad University Approved 2023-11-19 Ethics Committee in Biomedical Research, Mashhad Unit Mashhad, 14 Imam Khomeini Street, Faculty of Medicine, Azad University Mashhad Razavi Khorasan Iran (Islamic Republic of)