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IRCT20100314003566N13 IRCT 2023-12-02 Tabriz University of Medical Sciences Benefits of Nd:YAG 1064 nm laser in the treatment of the face and lower limb telangiectasia Determining the benefits and side effects of the Nd:YAG 1064 nm laser in order to achieve an effective pulse width with minimal side effects in the treatment of the face and lower limb telangiectasia 2023-12-22 anticipated 70 Complete https://irct.ir/trial/74056 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The degree of fluency, pulse width, and spot size utilized will be kept secret from patients. 3 Condition 1: Facial telangiectasia. Condition 2: Lower limb telangiectasia. Intervention 1: Intervention group 1: Patients with facial telangiectasia treated with alexandrite laser with a wavelength of 1064 nm (Alexandrite ND: YAG, CA, USA) with fluence parameters of 140 and 150 J/cm2 with a pulse width of 20 milliseconds and a spot size of 3 mm will be squared. Before the treatment, anesthesia will be done with a thin layer of topical gel on the surface of the skin. Also, after laser treatment, sunscreen and repair cream will be used in all patients for at least 10 days. Intervention 2: Intervention group 2: Patients with lower limb telangiectasia treated with alexandrite laser with a wavelength of 1064 nm (Alexandrite ND: YAG, CA, USA) with fluence parameters of 160 and 180 J/cm2 with a pulse width of 20 milliseconds and a spot size of 5 mm will be squared. Before the treatment, anesthesia will be done with a thin layer of topical gel on the surface of the skin. Also, after laser treatment, sunscreen and repair cream will be used in all patients for at least 10 days. Yes - There is a plan to make this available What will be shared: Study data is categorized and coded with no identifiable individuals. When: Access to study data after publication of the result is available in the journal. To whom: Anyone interested in using the data can access the study data. Conditions: Study data can be used for comparison with other results. Where to obtain: Refer to the study's scientific or public accountability person for data. How to obtain: The request will be sent by email to person responsible for scientific or public inquiries. Comments:
public Dr. Hamide Azimi
Sina hospital, Azadi avenue
Tabriz Iran (Islamic Republic of) 5138663134 +98 41 1540 6612 azimi@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Dr. Hamide Azimi
Sina hospital, Azadi avenue
Tabriz Iran (Islamic Republic of) 5138663134 +98 41 1540 6612 azimi@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Patients with facial telangiectasia Patients with telangiectasia of lower limbs Consent to participate in the study 18 years 50 years Both Pregnant and lactating women Patients with a history of coagulation disorders Suffering from chronic systemic liver diseases Patients with a history of hypertrophic scars and prone to keloid I78.0 I78.0 Hereditary hemorrhagic telangiectasia Hereditary hemorrhagic telangiectasia Treatment - Devices Treatment - Devices Intervention group 1: Patients with facial telangiectasia treated with alexandrite laser with a wavelength of 1064 nm (Alexandrite ND: YAG, CA, USA) with fluence parameters of 140 and 150 J/cm2 with a pulse width of 20 milliseconds and a spot size of 3 mm will be squared. Before the treatment, anesthesia will be done with a thin layer of topical gel on the surface of the skin. Also, after laser treatment, sunscreen and repair cream will be used in all patients for at least 10 days. Intervention group 2: Patients with lower limb telangiectasia treated with alexandrite laser with a wavelength of 1064 nm (Alexandrite ND: YAG, CA, USA) with fluence parameters of 160 and 180 J/cm2 with a pulse width of 20 milliseconds and a spot size of 5 mm will be squared. Before the treatment, anesthesia will be done with a thin layer of topical gel on the surface of the skin. Also, after laser treatment, sunscreen and repair cream will be used in all patients for at least 10 days. Recovery rate of telangiectasia. Timepoint: Patients will be examined at baseline, 4 weeks after the first treatment, 4 weeks after the second treatment, and 4 weeks after the last evaluation. Method of measurement: Dermoscopy imaging. Patient satisfaction. Timepoint: Patients will be examined at baseline, 4 weeks after the first treatment, 4 weeks after the second treatment, and 4 weeks after the last evaluation. Method of measurement: Interview with patients. Side effects. Timepoint: Patients will be examined at baseline, 4 weeks after the first treatment, 4 weeks after the second treatment, and 4 weeks after the last evaluation. Method of measurement: Including wounds, scars, erythema, hyperpigmentation, hypopigmentation and blisters, which will be evaluated by a clinical examination by a dermatologist. Tabriz University of Medical Sciences Approved 2023-11-20 Ethics Committee Of Tabriz University Of Medical Sciences. Third Floor, Central Building of Number 2, Golgasht Street Tabriz East Azarbaijan Iran (Islamic Republic of)