IRCT20231129060218N1 IRCT 2023-12-25 Yasouj University of Medical Sciences Quetiapine and Trazodone Effects on Sleep quality and Depression Severity in Patients with depressive disorder Investigation and Comparison of Quetiapine and Trazodone Effects on Sleep quality and Depression Severity in Patients with major depressive disorder 2023-12-29 anticipated 105 Complete https://irct.ir/trial/74022 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To create a simple random sequence from randomization on the web (www.graphpad.com) and to hide the random allocation, the method of closed envelopes will be used, a number of envelopes, prepared and inside each of the In the letters, the relevant drugs are placed. Finally, the lid of the envelope is glued and delivered to the participants, Blinding description: The patient receives the medicine in a sealed envelope witch is coded Coding is done by one of the colleagues of the project and the patients are blind. 3 Major depressive disorder. Intervention 1: Intervention group: first؛ use Trazadone drug. Intervention 2: Intervention group: second; use Quetiapine drug. Intervention 3: Control group: thirth; use placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information