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IRCT201203116934N2 IRCT 2012-05-30 Pharmaceutical research center, Tabriz University of Medical Sciences The effect of combinant antioxidant supplementation on blood in patient with rheumatoid arthritist The effect of combinant antioxidant supplementation on blood ADMA and VEGF levels and clinical outcomes in patient with rheumatoid arthritist 2012-06-20 anticipated 40 Complete https://irct.ir/trial/7394 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Rhumatoid arthritis. A tablet supplementation antioxidant compounds, including supplementation with a combination of selenium, zinc, vitamin A, E and C to form oral supplement "Celine Plus" is the order of 50 mg, 8 mg, 400 mg, 40 mg and 125 mg are. will be given to patients after Q Miran disease activity ADMA, VEGF was measured before and after study.
public Sousan Kolai
rheumatology departmant,imam reza hospital
Tabriz Iran (Islamic Republic of) +98 41 1337 1217 susan.kolahi@gmail.com Tabriz University of Medical Sciences scientific Sousan Kolahi
Imam Reza hospital, Golgasht Avenue
Tabriz Iran (Islamic Republic of) +98 41 1337 1217 susan.kolahi@gmail.com Pharmaceutical Research Center Iran (Islamic Republic of) People with diagnosis of Rheumatoid arthritis disease according to American College of Rheumatology criteria (ACR) is confirmed. The doctor diagnosed according to criteria ACR (at least 4 criteria for six weeks : 1 - morning stiffness in the joint for at least an hour or more 2 - articular arthritis in three areas or more4: hand joint arthritis 5- symmetrical arthritis 5 - rheumatoid nodules 6 - positive rheumatoid factor 7 - typical radiographic changes in the wrist and hand) in adult patients with rheumatoid arthritis and patients visiting the doctor, at least for the past two months have not had a treatment change. Selected at random from among eligible women 30 -60 years old admitted with mild to moderate range of severity of illness would be a specialist; if DAS (Disease Activity Score) below 3/2 is a mild disease and the DAS (Disease Activity Score) is between 3/2-5/1, moderate severity is defined . 30 years 60 years Female MO5 Seropositive rheumatoid arthritis Treatment - Drugs A tablet supplementation antioxidant compounds, including supplementation with a combination of selenium, zinc, vitamin A, E and C to form oral supplement "Celine Plus" is the order of 50 mg, 8 mg, 400 mg, 40 mg and 125 mg are. will be given to patients after Q Miran disease activity ADMA, VEGF was measured before and after study Determine and compare the clinical improvement in patients with rheumatoid arthritis before and after intervention. Timepoint: Before and 3 month after intervention. Method of measurement: DAS questionnaire. ADMA concentrations in the serum of patients with rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Previous intervention three months after the intervention began. Method of measurement: ELISA method. Determine changes in serum VEGF rheumatoid arthritis before and three months after the administration of antioxidants. Timepoint: Before and 3 month after intervention. Method of measurement: ELISA. Investigate the effects of antioxidant drugs. Timepoint: Before and three months after intervention. Method of measurement: Questionnaire. Pharmaceutical research center, Tabriz University of Medical Sciences Approved 2011-10-28 Tabriz University of Medical Sciences Ethics Committee Tabriz University of Medical Sciences Building, 3rd Floor Research Tabriz Iran (Islamic Republic of)