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IRCT20180912041018N3 IRCT 2023-11-20 Semnan University Investigation of the effect of selenium and exercise on the elderly The effect of eight weeks of selenium supplementation and Concurrent training on SOD, CAT, CRP, GPX, GR and lipid profile in elderly men 2024-01-10 anticipated 56 Complete https://irct.ir/trial/73645 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Factorial, Purpose: Supportive, Randomization description: After finalizing the 48 subjects and assigning codes 1 to 48 to each subject individually and using the PASS 2023 software (NCSS, LLC, Kaysville, Utah, USA, ncss.com/software/pass), the subjects were will be randomly divided into 6 groups of 8 people, Blinding description: This research will be done in a double blind way. After explaining the conditions and how to conduct the research to the subjects, they will be divided into six groups. Supplemental group, placebo group, control group, concurrent training group, concurrent training+supplement group, concurrent training+placebo group. None of the participants, the executive staff of nurses, physiotherapists, etc., practitioners and students (researcher) will know about the contents of the capsules. Which group will use the supplement and which group will use the placebo, the subjects and the researcher will not know. And this work will be determined by a third party as a reference person. In this way, the capsules containing placebo and supplement will be coded and provided by the researcher to the specified groups. At the end of the research and after collecting the blood sample and measuring the dependent variables, the data will be collected and provided to the supervisor, and after the data analysis and the results are determined, the codes will be opened and the supplement and placebo groups will be determined. 4 Aging. Intervention 1: Intervention group 1: Concurrent training, 3 sessions per week, 60 minutes in the morning, strength and endurance training protocol will be performed on every other day and on even days. Intervention 2: Intervention group 2: Supplement who will consume 200 micrograms of Selenium supplement with Nature med brand made in the USA. Intervention 3: Intervention group 3: Concurrent training and supplementation, in addition to implementing the weekly Concurrent training protocol, three sessions of 60 minutes per session will consume 200 micrograms of selenium supplement daily. Intervention 4: Intervention group 4: Placebo, who will consume a capsule containing roasted wheat flour and similar to the capsule containing selenium. Intervention 5: Intervention group 5: Exercise and placebo, in addition to implementing the Concurrent training protocol three sessions a week, each session will take 60 minutes a day, a capsule containing a placebo (roasted wheat flour) and completely similar to the selenium capsule. Intervention 6: Control group: The control will have the same conditions as the other groups and will not receive any of the interventions. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Rouhollah Haghshenas
5 km of Damghan road
Semnan Iran (Islamic Republic of) 35131-19111 0098 23 3342194 rhm@semnan.ac.ir Semnan University scientific Rouhollah Haghshenas
Standard Square
Semnan Iran (Islamic Republic of) 35131-19111 +98 23 3336 3494 rhm@semnan.ac.ir Semnan University Iran (Islamic Republic of) The age range of the subjects should be between 65 and 75. Subjects must be able to perform daily activities and physical activity. 65 years 75 years Male Use of antioxidant supplements up to 6 months before conducting the research Having chronic diseases, such as cardiovascular diseases, diabetes, acute joint disease, osteoporosis, bone fractures Z10 Factors influencing health status and contact with health services, Routine general health check-up of defined subpopulation, Rehabilitation Other Rehabilitation Placebo Placebo Other Intervention group 1: Concurrent training, 3 sessions per week, 60 minutes in the morning, strength and endurance training protocol will be performed on every other day and on even days. Intervention group 2: Supplement who will consume 200 micrograms of Selenium supplement with Nature med brand made in the USA. Intervention group 3: Concurrent training and supplementation, in addition to implementing the weekly Concurrent training protocol, three sessions of 60 minutes per session will consume 200 micrograms of selenium supplement daily. Intervention group 4: Placebo, who will consume a capsule containing roasted wheat flour and similar to the capsule containing selenium. Intervention group 5: Exercise and placebo, in addition to implementing the Concurrent training protocol three sessions a week, each session will take 60 minutes a day, a capsule containing a placebo (roasted wheat flour) and completely similar to the selenium capsule. Control group: The control will have the same conditions as the other groups and will not receive any of the interventions. Glutathione peroxidase. Timepoint: Measurement of glutathione peroxidase at the beginning of the study (before the start of the intervention) and 48 hours after the last training session. Method of measurement: By ELISA method and using ELISA kit. Glutathione reductase. Timepoint: Measurement of Glutathione reductase at the beginning of the study (before the start of the intervention) and 48 hours after the last training session. Method of measurement: by ELISA method and using ELISA kit. C Reactive Protein. Timepoint: Measurement of C-reactive protein at the beginning of the study (before the start of the intervention) and 48 hours after the last training session and in the fasting state. Method of measurement: By ELISA method and using ELISA kit. Superoxide Dismutase. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and in the fasting state. Method of measurement: By ELISA method and using ELISA kit. Catalase. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and in the fasting state. Method of measurement: By ELISA method and using ELISA kit. Low-density lipoproteins. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and fasting state. Method of measurement: ELISA method and use of ELISA kit. Very low density lipoprotein. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and fasting state. Method of measurement: ELISA method and use of ELISA kit. Cholesterol. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and fasting state. Method of measurement: ELISA method and use of ELISA kit. Triglyceride. Timepoint: At the beginning of the study (before the start of the intervention) and 48 hours after the last training session and fasting state. Method of measurement: ELISA method and use of ELISA kit. Semnan University Approved 2023-07-31 Semnan University of Medical Sciences and Health Services Headquarter of Semnan University of Medical Sciences and Health Services, Bassij Blvd, Semnan, Iran. Semnan Semnan Iran (Islamic Republic of)