IRCT20231108059991N1 IRCT 2023-12-28 Sabzevar University of Medical Sciences Determining the effect of hypothermia in improving peripheral neuropathy caused by chemotherapy drugs Evaluation of employing hypothermia for prevention of chemotherapy-induced peripheral neuropathy (CIPN) 2024-01-21 anticipated 60 Complete https://irct.ir/trial/73640 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: According to the sample size of the present study, the random allocation of the intervention in two groups will be done with the permutation block method. N/A chemotherapy induced neuropathy. Intervention 1: Intervention group: Patients in this group from the time of commencing chemotherapy (or simultaneously with premedication), during the time of receiving the chemotherapy and 15 minutes after it will use the foot wrap and hand wrap connected to the cooling unit for both hands and/or feet. The device continuously maintains the surface temperature of hands and feet in the range of 3 to 5 degrees Celsius. Intervention 2: Control group: Patients in this group will not use any foot wrap and hand wrap during chemotherapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is A decision will be made after the recruitment.