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IRCT20230717058811N1 IRCT 2023-10-16 Ahvaz University of Medical Sciences Investigation and effect of intravenous injection of dexamethasone and magnesium sulfate on pain Study the Effect of Intravenous of Dexamethasone versus Magnesium Sulphate on postoperative pain after laparoscopic Cholecystectomy surgery 2023-06-20 anticipated 60 Complete https://irct.ir/trial/73157 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the samples will be divided into two similar groups of 30 people using a table of random numbers, and in the pre-surgery visit, the necessary examinations will be performed, then 15 minutes before the start of anesthesia, 6 cc/kg of Ringer's normal saline will be administered to the patients. will be given and full monitoring including NIBP/ECG/pulse oximetry will be done, demographic information (age, gender, weight) and vital signs will be recorded in the questionnaire, Blinding description: 60 patients with inclusion criteria will be used in the simple random allocation method with placement. In this way, 60 numbers will be poured into a container, and for each patient, after obtaining informed consent, an envelope will be drawn from the container, and based on the odd or even numbers, they will be divided into two groups: dexamethasone and magnesium sulfate. will be allocated. The even numbers will form the dexamethasone group and the odd numbers will form the magnesium sulfate group, then in order to blind the study, the patient and the researcher and the person who will complete the questionnaires will not know the type of injectable drug and the group under investigation. 3 Pain after head cystectomy surgery. Intervention 1: Intervention group: Patients in group M will be given a bolus dose of 50 mg/kg magnesium sulfate in 15 minutes and an infusion of 10 mg/kg magnesium sulfate in normal saline until the end of the operation. Intervention 2: Intervention group: Group D will be given 1 mg/kg intravenous dexamethasone 15 minutes before induction and 0.4 mg/kg/h as an infusion during the procedure. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I haven't decided yet, the release schedule is not clear yet
public Tirazheh Hazrati Yadkoori
24 metery street, east sahely highway, ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 +98 912 890 7911 hazrati.t@ajums.ac.ir Ahvaz University of Medical Sciences scientific Tirazheh Hazrati Yadkoori
24 metery street, east sahely highway, ahvaz
Ahvaz Iran (Islamic Republic of) 6193673166 +98 912 890 7911 hazrati.t@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Patients between 18-70 years old Candidate for elective laparoscopic cere cystectomy surgery Action satisfaction 18 years 70 years Both known allergy to one of the study drugs (dexamethasone/magnesium sulfate) Liver-kidney-heart dysfunction History of taking steroid drugs before surgery Neuromuscular disease Opioid or analgesic use within 3 days before the study Taking calcium channel blockers Failure to sign written consent K91.86 Retained cholelithiasis following cholecystectomy Treatment - Surgery Treatment - Surgery Intervention group: Patients in group M will be given a bolus dose of 50 mg/kg magnesium sulfate in 15 minutes and an infusion of 10 mg/kg magnesium sulfate in normal saline until the end of the operation. Intervention group: Group D will be given 1 mg/kg intravenous dexamethasone 15 minutes before induction and 0.4 mg/kg/h as an infusion during the procedure. Visual Analogue Scale (VAS). Timepoint: Based on the VAS criteria at certain times (immediately after induction, one hour, two hours and 24 hours after the operation). Method of measurement: After the surgery, the patient will be monitored for 2 hours in recovery and the pain intensity of the patients will be measured and recorded every half hour by a person who is not aware of the groups. Ahvaz University of Medical Sciences Approved 2023-06-20 Ethics Committee in Golestan Hospital Research Golestan Ave, Golestan Hospital Ahvaz Khouzestan Iran (Islamic Republic of)