IRCT20160307026950N54 IRCT 2023-10-17 Esfahan University of Medical Sciences study of the combination of dexmedetomidine-propofol, dexmedetomidine and propofol for sedation Comparative study of the combination of dexmedetomidine-propofol, dexmedetomidine and propofol for sedation during mechanical ventilation in patients hospitalized in the intensive care unit 2023-10-23 anticipated 90 Complete https://irct.ir/trial/73156 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done in a simple way. The samples are randomly placed in three intervention groups 1, 2 and 3 by means of random allocation software. Sampling continues until the samples in all three groups reach the set limit, Blinding description: This study is a three-way blind clinical trial, so that the patient is included in the study but does not know the type of intervention applied and is blind, the person who records the patient's symptoms is also different from the person who injects the medicine. And without knowing the type of medicine, he only records the patient's symptoms during the study and therefore is kept blind. The analysts who analyze the data collected during the study also do not know the type of intervention applied in each group and are blind. 3 Need for sedation during mechanical ventilation. Intervention 1: Intervention group: In the first group, the loading dose of dexmedetomidine was 1 µg kg–1 h–1 within 10 minutes and then the infusion 0.1 µg kg–1h–1. Intervention 2: Intervention group: In the second group, propofol (1%) loading dose of 1 mg kg-1 within 10 minutes and then infusion of 1 mg kg-1 kg-1h-1. Intervention 3: Intervention group: In the second group, propofol (1%) loading dose of 1 mg kg-1 within 10 minutes and then infusion of 1 mg kg-1 kg-1h-1. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information