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IRCT20231007059641N1 IRCT 2023-12-28 Kashan University of Medical Sciences The effect of selective oral decontamination regimen and chlorhexidine on rate of ventilator-associated pneumonia Comparison of the effect of selective oral decontamination regimen and chlorhexidine on rate of ventilator-associated pneumonia in patients admitted to the intensive care unit care of Beheshti hospital in Kashan 2023 2023-11-22 anticipated 96 Complete https://irct.ir/trial/73025 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The samples will be determined by block randomization method with 10 blocks and using the random number table of Allocation Random software. Blocking and allocation sequencing for concealment will be done by the person not involved in the research (Allocation Concealment).The sample allocation ratio (Allocation 1:1) will be in two groups of intervention and control (Assignment). Then, based on the obtained blocks and in the order of allocation, the intervention will be done. Blinding will not occur in this study. N/A Ventilator associated pneumonia. Intervention 1: First intervention group: Each patient will be rinsed with 2% chlorhexidine solution every 6 hours for 4 days by the researcher. Intervention 2: The second intervention group: Each patient will be rinsed every 6 hours for 4 days using SOD solution containing 2% vancomycin, 2% gentamicin and 2% colistin by the researcher. Intervention 3: Control group: No intervention will be done by the researcher and they will receive routine ward care (drug therapy, mouthwash if necessary). No - There is not a plan to make this available Justification or reason for not sharing IPD is Data of participants are confidential.
public Mahdye Sabery
School of Nursing and Midwifery, Kashan university of medical sciences, Parastar St., Qotbe Ravandi Blv, Kashan, Iran
Kashan Iran (Islamic Republic of) 8715981151 +98 31 5510 3140 Dsabery@yahoo.com Kashan University of Medical Sciences scientific Mahdye Sabery
School of Nursing and Midwifery, Kashan university of medical sciences, Parastar St., Qotbe Ravandi Blv, Kashan, Iran
Kashan Iran (Islamic Republic of) 8715981151 +98 31 5510 3140 Dsabery@yahoo.com Kashan University of Medical Sciences Iran (Islamic Republic of) Age between18 to 65 years old Not having diseases such as cancer, diabetes and chronic obstructive pulmonary disease Not using drugs that weaken the immune system 18 years 65 years Both Having more than 48 hours of mechanical ventilation before admission Requiring CPR J18.9 Pneumonia, unspecified Prevention Prevention Prevention First intervention group: Each patient will be rinsed with 2% chlorhexidine solution every 6 hours for 4 days by the researcher. The second intervention group: Each patient will be rinsed every 6 hours for 4 days using SOD solution containing 2% vancomycin, 2% gentamicin and 2% colistin by the researcher Control group: No intervention will be done by the researcher and they will receive routine ward care (drug therapy, mouthwash if necessary). Ventilator-associated pneumonia. Timepoint: At the time of admission and 96 hours after that. Method of measurement: To investigate pneumonia, the patient's body temperature using a mercury thermometer, the number of blood leukocytes using a venous blood test, pulmonary infiltration using chest X-ray, tracheal tube secretions using suction, Pao2 using ABG and fio2 using Pulse oximetry is measured. Kashan University of Medical Sciences Approved 2023-09-10 Ethics committee of Kashan University of Medical Sciences School of Nursing and Midwifery, Kashan university of medical sciences, Parastar St., Qotbe Ravandi Blv, Kashan, Iran Kashan Isfehan Iran (Islamic Republic of)