]>
IRCT20130518013364N11 IRCT 2023-09-27 Shahid Beheshti University of Medical Sciences Comparison of intra-articular injection of dexmedetomidine and triamcinolone in improving knee pain and function in patients with primary knee osteoarthritis. Comparison of efficacy and safety of intra-articular injection of dexmedetomidine and triamcinolone in improving knee pain and function in patients with primary knee osteoarthritis 2023-10-02 anticipated 60 Complete https://irct.ir/trial/72679 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Health service research, Randomization description: A simple randomization is done with sealed envelope tools in such a way that the letters A and B are inserted in the envelopes and patients are asked to select an envelope that the intervention group A and the group B will be as control group, Blinding description: The patient herself and the doctor who evaluates the outcome in patients do not know the patient group (intervention group or control group). 2-3 Osteoarthritis of knee. Intervention 1: Intervention group: Injection of dexmedetomidine 1 microgram per kilogram + 2 ml lidocaine 2%, which is performed under ultrasound guidance with a 27-gauge needle inside the knee joint. The injection is done in one session. Intervention 2: Control group: Injection of one milliliter (40 mg) of triamcinolone + 2 ml of lidocaine 2%. The injection method is similar to the intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Mehrdad Taheri
Shahid Madani street, Imam Hossein Hospital
Tehran Iran (Islamic Republic of) 1617763141 +98 21 7343 0000 m.taheri@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific Mehrdad Taheri
Shahid Madani street, Imam Hossein Hospital
Tehran Iran (Islamic Republic of) 1617763141 +98 21 7343 0000 m.taheri@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Age over 40 years Presence of knee pain for more than 3 months Radiological findings confirming knee osteoarthritis based on American College of Rheumatology (ACR) criteria 40 years no limit Both Unwillingness to participate in the study Patients with a history of knee surgery Patients with lower limb deformity and contracture Patients with lower limb neuromuscular disease Patients with acute lumbar pathology Injection of steroid drugs during the last two months History of inflammatory rheumatoid arthritis History of recent infection in the knee Diabetes Pregnancy Breastfeeding BMI> 35 Candidate patients for knee surgery The presence of knee deviation (Varus or valgus more than five degrees) which was confirmed by three joint view The presence of radicular pain Taking anticoagulants Arthritis after trauma History of intra-articular injection of the knee during the last 12 months Allergy to any of the drugs used Chronic systemic disease Psychiatric illness Severe osteoarthritis with grade more than III Hepatitis Cytomegalovirus infection Having syphilis Having osteomyelitis Drug and alcohol abuse Having AIDS M17.0 Bilateral primary osteoarthritis of knee Treatment - Other Treatment - Other Intervention group: Injection of dexmedetomidine 1 microgram per kilogram + 2 ml lidocaine 2%, which is performed under ultrasound guidance with a 27-gauge needle inside the knee joint. The injection is done in one session. Control group: Injection of one milliliter (40 mg) of triamcinolone + 2 ml of lidocaine 2%. The injection method is similar to the intervention group. Pain. Timepoint: At the beginning of the study (before the start of the intervention) and one and three months after. Method of measurement: Visual analog scale. The total score of the KOOS questionnaire. Timepoint: At the beginning of the study (before the start of the intervention) and one and three months after. Method of measurement: Based on asking the patient and scoring each of the items. Shahid Beheshti University of Medical Sciences Approved 2023-07-30 Ethics committee of Shahid Beheshti University of Medical Sciences Shahid Abbas Arabi Street, Yemen Street, Shahid Chamran highway, Shahid Beheshti University Of Medical Sciences Tehran Tehran Iran (Islamic Republic of)