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IRCT20190624043991N20 IRCT 2023-09-25 Tehran University of Medical Sciences Antibiotic effect during and after intra-organ stone crushing Investigating the effect of antibiotics in washing fluid on inflammatory factors during and after transurethral lithotripsy: a single blind clinical trial 2024-02-09 anticipated 80 Complete https://irct.ir/trial/72633 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 80 study participants who meet the entry requirements will be randomly split into two equal groups of 40 participants. The randomization method of separate blocks is used to create quadruple blocks for randomization. The first patient's chosen illness will be assigned to the "first group," and the second patient will be assigned to the "second group". Patients are divided into two groups: 1-control group: 0.9% normal saline serum and 2-intervention group: 1000 mg of ceftriaxone antibiotic + 6 liters of 0.9% normal saline, Blinding description: The present study is a single-blind, randomized clinical trial study. The patient or participant will not know how to be placed in the control or intervention groups. 3 Urinary tract infection. Intervention 1: Intervention group: Intervention group: 1000 mg ceftriaxone antibiotic + 6 liters of normal saline 0.9%. they receive. Intervention 2: Control group: control group: normal saline serum 0.9. Yes - There is a plan to make this available What will be shared: Demographic information anonymously When: One year after publication To whom: En Researchers working in academia, physicians, surgeons and hospitals Conditions: En Any analysis can be done with the consent of the main researcher Where to obtain: Sina Hospital, Urology Research Center, Head of Urology Research Center: Dr. Seyed Mohammad Kazem Aghamir 00982166348560 How to obtain: En After reviewing the information by the administrator and epidemiologist, the patient information will be available for the applicant by the provision of a patient's privacy. Comments:
public Dr Akram Mirzaei
Tehran
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6634 8560 mirzaee.scholar@gmail.com Tehran University of Medical Sciences scientific Dr Mohammad Kazem Aghamir
Urology Research Center- Sina Hospital - Imam Khomeini St
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6634 8560 mkaghamir@tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Patients in the study and obtaining informed consent aged between 20 and 70 years elective surgery stones smaller than 20 million meters located in the upper lower ureter in CTS without contrast. 20 years 70 years Both Previous history of urinary system surgery Having simultaneous kidney stones Having anatomical or functional kidney disorders Bilateral ureteral stones Positive urine culture before surgery Use of corticosteroids or antibiotics before surgery Immunodeficiency Taking drugs Causes of immunodeficiency Any active or chronic infection during the last three months Diabetes N39.0 Urinary tract infection, site not specified Treatment - Drugs Treatment - Drugs Intervention group: Intervention group: 1000 mg ceftriaxone antibiotic + 6 liters of normal saline 0.9%. they receive Control group: control group: normal saline serum 0.9 The effect of antibiotics in the lavage fluid on the occurrence of infections during and after intra-organ stone crushing. Timepoint: 6-12 hours after surgery. Method of measurement: Laboratory diagnosis (urine culture and inflammatory markers). Tehran University of Medical Sciences Approved 2023-01-15 Ethics Committees in Medical Medical Research Room 604, Sixth Floor, Central Staff Building, Tehran University of Medical Sciences, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)