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IRCT20181030041503N7 IRCT 2023-11-02 Mashhad University of Medical Sciences Effect of GnRH agonist and letrozole treatment in women with recurrent implantation failure Comparison of pregnancy rate after frozen embryo transfer in two methods of endometrial preparation: using GnRH agonist together with letrozole and GnRH agonist alone in women with recurrent implantation failure 2023-10-02 anticipated 60 Complete https://irct.ir/trial/72623 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization. -In this randomized clinical trial involving 60 women (18-40 years), two groups were randomly assigned. Randomization will be by block method. In this study, 6 quadruple blocks (AABB(1)- ABAB(2)-ABBA(3)-BBAA(4)- BABA(5)- BAAB(6)) will be the sampling guide. Then the list of blocks will be written and numbers will be assigned to them, then random numbers between 1 to 6 (eg 1, 4, 5, etc.) will be selected using the numbers site. http://www.graphpad.com/quickcalcs/index. cfm. 3 Infertility. Intervention 1: Intervention group: In the intervention group, treatment with GnRH agonist, decapeptyl ampoule with a dose of 3.75 mg intramuscular (Varian Pharmed Pharmaceutical Company) along with letrozole 5 mg daily (Iran Hormone Pharmaceutical Company) is prescribed for two months and during the next period if suppression of ovaries and uterus are confirmed (including absence of cysts and thickness of the uterus less than 5 mm), treatment with oral estradiol is started. Intervention 2: Intervention group: in the control group, the GnRH agonist (decapeptyl intramuscular injection with a dose of 3.75 mg) will be started on the 21st day of the previous cycle, and estradiol will be prescribed from the second day of menstruation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I'm looking into the matter
public malihe mahmoudinia
Imam Reza Hospital, Imam Reza St., Mashhad, Iran
mashhad Iran (Islamic Republic of) 9178943791 +98 51 3853 4021 mahmoudiniam@mums.ac.ir Mashhad University of Medical Sciences scientific malihe mahmoudinia
Imam Reza Hospital, Imam Reza St., Mashhad, Iran
mashhad Iran (Islamic Republic of) 9178943791 +98 51 3583 1204 mahmoudiniam@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Infertile women (18-40 years) with a history of at least two failed embryo transfers and at least 5 good-quality embryos have been transferred. Document of the normal uterine cavity normal test of TSH, Prolactin and thrombophilia lack of confirmed endometriosis and Endometrioma Lack of fibroma greater than 4 centimeters. 18 years 40 years Female patient dissatisfaction during treatment to continue the study The presence of pathology endometrial N98.3 Complications of attempted introduction of embryo in embryo transfer Placebo Placebo Intervention group: In the intervention group, treatment with GnRH agonist, decapeptyl ampoule with a dose of 3.75 mg intramuscular (Varian Pharmed Pharmaceutical Company) along with letrozole 5 mg daily (Iran Hormone Pharmaceutical Company) is prescribed for two months and during the next period if suppression of ovaries and uterus are confirmed (including absence of cysts and thickness of the uterus less than 5 mm), treatment with oral estradiol is started. Intervention group: in the control group, the GnRH agonist (decapeptyl intramuscular injection with a dose of 3.75 mg) will be started on the 21st day of the previous cycle, and estradiol will be prescribed from the second day of menstruation. Chemical pregnancy rate. Timepoint: 2 week after embryo transfer. Method of measurement: BHCG. The rate of clinical pregnancy. Timepoint: 6 weeks after embryo transfer. Method of measurement: Sonography. Ongoing pregnancy. Timepoint: Continue pregnancy for up to 12 weeks. Method of measurement: Sonography. Mashhad University of Medical Sciences Approved 2020-10-29 Mashhad university of medical sciences Ethics committee Imam Reza Hospital, Imam Reza St., Mashhad, Iran mashhad Razavi Khorasan Iran (Islamic Republic of)