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IRCT20190208042655N3 IRCT 2024-01-29 Tehran University of Medical Sciences Evaluation of progesterone suppository in reducing preterm labor in high uterocervical angle Evaluation of the effect of progesterone suppository on reducing the rate of preterm labor in patients with utererocervical angle above 105 ° 2024-02-20 anticipated 42 Complete https://irct.ir/trial/72486 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: According to the table of random numbers, patients are classified into one of two intervention or control groups, Blinding description: In this study, after entering the mentioned study and filling out the informed consent form to participate in the study, and explaining the desired intervention in each group , according to the table of random numbers, the patients are placed in one of the two intervention or control groups. Finally, data analysis will be done by a third person who is completely blinded about the control and intervention groups. 3 preterm labor. Intervention 1: Intervention group: Pregnant women with a uterocervical angle above 105 degrees, receive 400 mg of vaginal progesterone suppositories daily (Aborehan Company) from 18-20 weeks to 36 weeks of pregnancy. Intervention 2: Control group: Pregnant women with uterocervical angle above 105 degrees and normal cervical length without receiving medication. Yes - There is a plan to make this available What will be shared: All data are available in SPSS file When: 3 months after the publication of the article To whom: Researchers working in academic institutions Conditions: If the data is needed and used to provide the proposal to the executor of the project, the right of the executor and the co-author of the project should be respected. Where to obtain: Send via email nsaedi@sina.tums.ac.ir request How to obtain: First, the reason for the request and proposal of the proposed project will be sent to nsaedi@sina.tums.ac.ir address, and then, if the executor agrees, taking into account the agreement between the parties to protect the rights of the executors of the project, it will be sent via email and in the form of SPSS file. Comments:
public Nafiseh Saedi
sattarkhan
Tehran Iran (Islamic Republic of) 1597856511 +98 21 8886 3994 nsaedi@sina.tums.ac.ir Tehran University of Medical Sciences scientific Nafise Saedi
sattarkhan
Tehran Iran (Islamic Republic of) 1597856511 +98 21 8886 3994 nsaedi@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) All women aged 18-45 A singleton pregnancy carrier No history of premature birth 18 years 45 years Female history of preterm labor history of second-trimester abortion cervical length below 30 mm O34.32 Maternal care for cervical incompetence, second trimester Prevention Prevention Intervention group: Pregnant women with a uterocervical angle above 105 degrees, receive 400 mg of vaginal progesterone suppositories daily (Aborehan Company) from 18-20 weeks to 36 weeks of pregnancy. Control group: Pregnant women with uterocervical angle above 105 degrees and normal cervical length without receiving medication. The effect of progesterone suppositories in reducing premature labor. Timepoint: delivery time. Method of measurement: Investigation of preterm birth under 37 weeks of pregnancy. The effect of progesterone suppositories on changing the uterocervical angle one month after receiving suppositories. Timepoint: One month after receiving progesterone suppositories. Method of measurement: with Philips Affinity 70 ultrasound machine and with vaginal probe 1-10. Tehran University of Medical Sciences Approved 2023-08-29 Research Ethics Committees of Imam Khomeini Hospital Complex- Tehran University of Medical Sciences Sattar Khan Street, Imam Khomeini Hospital Complex, Women's Department tehran Tehran Iran (Islamic Republic of)