]>
IRCT20200322046833N3 IRCT 2024-01-04 Tehran University of Medical Sciences Comparing the effectiveness of injectable pantoprazole, oral pantoprazole and injectable famotidine for stress ulcer prophylaxis in the intensive care unit. Comparing the effectiveness of injectable pantoprazole, oral pantoprazole and injectable famotidine for stress ulcer prophylaxis in the intensive care unit. 2023-10-23 anticipated 60 Complete https://irct.ir/trial/72467 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients are divided into three parallel groups by simple random number table. 2 gastric stress ulcer prophylaxes. Intervention 1: Intervention group: intravenous pantoprazole. Intervention 2: Intervention group: intravenous famotidine. Intervention 3: Intervention group: oral pantoprazole. Yes - There is a plan to make this available What will be shared: Clinical results will be published through an original article and All other data will be available on request When: Up to 5 years after publishing the clinical results To whom: Researchers and ethics committee Conditions: Ethical evaluation and review articles without financial conflicts of interest. Where to obtain: Responsible Researcher Dr Farhad Najmeddin by the following email f-najmeddin@tums.ac.ir How to obtain: Data will be available within 2 weeks after the email check. The email should include the Conflict of interest disclosure Comments:
public Farhad Najmeddin
Sina Hospital, Imam Khomeini St, Hasanabad Square, Tehran, Iran
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6634 8500 f-najmeddin@sina.tums.ac.ir Tehran University of Medical Sciences scientific Farhad Najmeddin
Sina Hospital, Imam Khomeini St, Hasanabad Square, Tehran, Iran
Tehran Iran (Islamic Republic of) 1136746911 +98 21 6634 8500 f-najmeddin@sina.tums.ac.ir Tehran University of Medical Sciences Iran (Islamic Republic of) Patients over 18 years of age hospitalized in the intensive care unit who have a nasogastric tube and are indicated for the prevention of peptic ulcer. Sign the informed consent 18 years no limit Both Bariatric surgery Gastrectomy surgery Active gastrointestinal ulcer or gastrointestinal bleeding Stomach malignancy Patients who have received PPI and H2 Blocker drugs in the last 5 days Patients whose gastric acid base is above 5 K27 Peptic ulcer, site unspecified Prevention Prevention Prevention Intervention group: intravenous pantoprazole Intervention group: intravenous famotidine Intervention group: oral pantoprazole Frequency of occurrence of pH less than 5 during the study. Timepoint: On day 1,3,5 and 7 stomach pH of patients is determined by digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people), 3 times a day. Method of measurement: about 10 cc of stomach contents are aspirated one hour after gavage and measured with digital laboratory pH meter and paper pH meter (to avoid the optical error of litmus paper, it is confirmed by two people). Average changes of CRP/Alb - lymphocyte to neutrophil ratio - platelet to lymphocyte ratio on the first day compared to the seventh day in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. The number of days hospitalized in the intensive care unit in the group of injectable famotidine and injectable pantoprazole and oral pantoprazole in patients hospitalized in intensive care units. Mortality in the group of injectable famotidine and parenteral pantoprazole and oral pantoprazole in patients admitted to the intensive care unit. Timepoint: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded. Method of measurement: The inflammatory index CRP/Alb is checked on day 0 and day 7. The time of discharge from the intensive care unit or the death of patients is recorded. Tehran University of Medical Sciences Approved 2023-08-05 Ethics Committee of Sina Hospital - Tehran University of Medical Sciences Sina Hospital, Imam Khomeini St, Hasanabad Square, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)