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IRCT20230827059269N1 IRCT 2023-09-24 Qazvin University of Medical Sciences Comparison of the effect of injectable Acetaminophen with Ketamine injected on reducing acute pain after surgery Comparison of the effect of injectable Acetaminophen with Ketamine injected by Morphine pump on reducing acute pain after surgery 2023-09-11 anticipated 60 Complete https://irct.ir/trial/72326 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: This is a double-blind type of experiment, which will be blind for the people participating in the study and evaluating the outcome. In the consent form to participate in the study, it is written for the patient that his presence does not necessarily mean intervention but may be included in the control group. 3 Acute pain after surgery. Intervention 1: Intervention group: In test group A (Acetaminophen drug), after surgery, the patient enters the recovery department, and after fully regaining consciousness and expressing pain, the injection drug Acetaminophen with a dose of 1 mg by an infusion pump by an anesthesiologist as a pain reliever. Analgesic plus 10 mg of Morphine in 100 cc of Normal saline is injected intravenously to the patient at a rate of 4 drops per minute to reduce pain. Intervention 2: Intervention group: In test group B (Ketamine drug), after surgery, the patient enters the recovery department, and after fully regaining consciousness and expressing pain, the injection drug Ketamine with a dose of 1 mg by an infusion pump by an anesthesiologist as a pain reliever. Analgesic plus 10 mg of Morphine in 100 cc of Normal saline is injected intravenously to the patient at a rate of 4 drops per minute to reduce pain. Intervention 3: Control group: In the placebo group, after the surgery, the patient enters the recovery department, and after regaining consciousness and expressing pain, 10 mg of Morphine in 100 cc of Normal saline is injected intravenously at a rate of 4 drops per minute to reduce pain. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Satisfaction of participants
public Majid Golrezaei
Bahonar street
Qazvin Iran (Islamic Republic of) 34197-58911 +98 28 3333 6001 m.golrezaei@gmail.com Qazvin University of Medical Sciences scientific Majid Golrezaei
Bahonar street
Qazvin Iran (Islamic Republic of) 34197-58911 +98 28 3333 6001 m.golrezaei@gmail.com Qazvin University of Medical Sciences Iran (Islamic Republic of) Patients aged 15 to 60 are candidates for surgery 15 years 60 years Both History of surgery History of smoking, alcohol and drug abuse Chronic mental and physical illness (schizophrenia, diabetes, etc.) Vision and hearing problems and other disabilities Long-term use of corticosteroids, antihistamines, narcotics and painkillers Allergy to acetaminophen, ketamine, morphine Pregnancy and breastfeeding and abortion less than 3 months R52.0 Acute pain Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: In test group A (Acetaminophen drug), after surgery, the patient enters the recovery department, and after fully regaining consciousness and expressing pain, the injection drug Acetaminophen with a dose of 1 mg by an infusion pump by an anesthesiologist as a pain reliever. Analgesic plus 10 mg of Morphine in 100 cc of Normal saline is injected intravenously to the patient at a rate of 4 drops per minute to reduce pain. Intervention group: In test group B (Ketamine drug), after surgery, the patient enters the recovery department, and after fully regaining consciousness and expressing pain, the injection drug Ketamine with a dose of 1 mg by an infusion pump by an anesthesiologist as a pain reliever. Analgesic plus 10 mg of Morphine in 100 cc of Normal saline is injected intravenously to the patient at a rate of 4 drops per minute to reduce pain. Control group: In the placebo group, after the surgery, the patient enters the recovery department, and after regaining consciousness and expressing pain, 10 mg of Morphine in 100 cc of Normal saline is injected intravenously at a rate of 4 drops per minute to reduce pain. The amount of pain after the operation. Timepoint: 3, 6 and 12 hours after the operation. Method of measurement: Using a ruler-like grading system (Visual Analog Scale) from 0 (no pain) to 10 (the most severe pain imaginable). Qazvin University of Medical Sciences Approved 2022-02-15 Ethics committee of qazvin University of Medical Sciences Research and Technology deputy ,Mavaddat Alley,Shahid Beheshti Blvd,Qazvin Qazvin Qazvin Iran (Islamic Republic of)