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IRCT20230830059302N1 IRCT 2023-09-01 Self Sponsored Lidocaine as anesthetic adjuvant LAT TO STUDY THE PHARMACOKINETIC AND PHARMACODYNAMIC EFFECTS OF LIDOCAINE INFUSION ON POSTOPERATIVE ANALGESIA WITH RESPECT TO PHARMACOGENETICS 2023-10-02 anticipated 300 Complete https://irct.ir/trial/72325 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Other, Purpose: Supportive, Other design features: Interventional, Randomization description: An interventional, prospective, double-blind randomized study The solutions container was assigned the code A & B. Only the anesthetist knows which solution has to be given to the patient. The researcher and the patient were kept blind, Blinding description: An interventional, prospective, double-blind randomized study (62) The solutions container was assigned the code. Only the anesthetist knows which solution has to be given to the patient. The researcher and the patient were kept blind. 4 Patient undergoing Elective abdominal cholecystectomy. Intervention group:. Yes - There is a plan to make this available What will be shared: Patient aged between 18 to 60 years fufilling ASA criteria of I & II ubdergoing elective abmoniall cholecystectomy When: After the study completedfor 10 years To whom: To researchers Conditions: When someone wants the data he can contact me through email for availability Where to obtain: From me the researcher How to obtain: Through email Comments:
public Ayesha Afzal
Pharmacology Department, Wah Medical College
WAH CANTT Pakistan 47010 +92 301 5218240 dr.ayeshaafzal@hotmail.com Wah Medical College scientific Ayesha Afzal
Pharmacology Department, Wah Medical College,
WAH CANTT Pakistan 47010 +92 301 5218240 dr.ayeshaafzal@hotmail.com Riphah International University Pakistan • Healthy Pakistani individuals between ages 18-60 years undergoing elective abdominal cholecystectomy. • Patients in classes I and II of the American Society of Anesthesiologists (ASA) scale. 18 years 60 years Both • Not of Pakistani origin • Extremes of age • Patients in classes III, IV, V &, and VI of the ASA scale.• Patient with deranged Liver & renal function test (LFT/RFT) • Pre-operative morphine consumption• Patients on medication with immunosuppressive drugs, Non-steroidal anti-inflammatory drugs, or steroids if taking should stop them one week before surgery Treatment - Drugs Intervention group: To prove that lidocaine is a safe anesthetic adjuvant helps in early recovery and decreases the hospital load.by early mobilization. Timepoint: Samples will be taken at 0, 2, 4 & 6 hrs after the surgery. Method of measurement: BP by sphygmomonometer & plasma level of drugs by HPLC, Interleukin levels by ELISA kit, Genotyping by PCR & RFLP. Analgesia. Timepoint: VAS. Method of measurement: Facial expression, then after 8 hours through verbel questions. Inflammatory markers. Timepoint: IL levels decline earlier. Method of measurement: ELISA Kit. Self financed Approved 2023-06-15 BASAR Islamic International Medical College Rawalpindi Punjab Pakistan