IRCT20230828059282N1 IRCT 2023-10-24 Oroumia University of Medical Sciences Acetaminophen vs Ibuprofen in treatment of patent ductus arteriosus in premature infants with very low weight Comparison of the efficacy of parenteral Acetaminophen and oral Ibuprofen on the treatment of patent ductus arteriosus in premature infants with very low weight 2023-06-25 anticipated 40 Complete https://irct.ir/trial/72288 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the block randomization method will be used, so that at first all the possible states of the combination AABB will be listed, then according to the sample size (40) and the block size equal to 4, 10 blocks will be randomly selected. will be selected. The selection of randomization will be such that first all possible combinations of 4 will be listed and a code will be assigned for each, and then 10 blocks will be selected and listed in order, and the allocation of people will be based on this list. The codes will be secret and only available to the epidemiological consultant. All steps will be done under the supervision of an epidemiologist and using Random Allocation software, version one. N/A patent ductus arteriosus. Intervention 1: Intervention group: IV Acetaminophen 15mg/kg/Q6h. Intervention 2: Intervention group:Oral Ibuprofen suspansion 100mg/5ml with 10mg/kg/daily. No - There is not a plan to make this available Justification or reason for not sharing IPD is No further info