IRCT20120215009014N480 IRCT 2023-08-23 Hamedan University of Medical Sciences Comparison of the efficacy of hypertonic saline 5% with mannitol 20% on cerebral edema in ischemic and hemorrhagic stroke patients Comparison of the efficacy of hypertonic saline 5% with mannitol 20% on cerebral edema in ischemic and hemorrhagic stroke patients: a randomized clinical trial 2023-09-06 anticipated 100 Complete https://irct.ir/trial/72142 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, random assignment of patients to the intervention and control groups will be carried out using block randomization. To achieve this, four sheets of paper will be prepared - two with the name of the intervention and two with the name of the control. These paper sheets will be pooled and placed in a container. Patients will be selected one at a time without replacement, and for each patient, a paper sheet will be randomly drawn from the container. After each draw, the paper sheets will be returned to the container, and the process will be repeated until the desired sample size is reached. 3 Cerebellar stroke. Intervention 1: Intervention group: Mannitol 20% first with a dose of 1.5 gr/kg, then 100 ml every 4 hours within 15 to 20 minutes and repeating it until the patient regains consciousness. Intervention 2: Control group: Hypertonic saline 5% with a dose of 3 to 5 ml/kg and the same dose every 6 hours within 15 to 20 minutes and repeating it until the patient regains consciousness. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.