IRCT20230816059169N1 IRCT 2023-09-11 CMH Rawalpindi LIGNOCAINE AS ANALGESIA IN BURN PATIENTS EFFICACY OF INTRAVENOUS LIGNOCAINE AS ADJUVANT ANALGESIA IN BURN PATIENTS DURING CHANGE OF DRESSING UNDER GENERAL ANESTHESIA 2023-01-01 anticipated 90 Complete https://irct.ir/trial/72139 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients were divided into two groups after randomization in Group L (n=45) as the intravenous lignocaine group and Group A (n=45) as the non-adjuvant group without intravenous lignocaine. The method of randomization was non-probability consecutive sampling via lottery method. All the patients were thoroughly counselled regarding the procedure and in case the patients were unable to communicate, permission was taken from the next of kin. An informed written high-risk consent was taken for surgery, Blinding description: The participants in the study were briefed about the study protocol or how the results would be analyzed. 100 ml burettes containing the pre-mixed drug dose of lignocaine and one containing only normal saline were used to prevent observer bias. 1-2 Burns. Intervention 1: Intervention group: Group L (Intravenous lignocaine) Patients in Group L received intravenous lignocaine at a dose of 1.5 mg/kg infused over 5 minutes before induction whereas patient in Group A only received intravenous paracetamol and nalbuphine. Anesthesia was induced with intravenous propofol at 1.5 mg/kg, paralysis was achieved with atracurium 0.5 mg/kg and anesthesia was maintained with inhalational isoflurane at 1 MAC (minimum alveolar concentration). Intervention 2: Control group: Group A (Normal saline group) is the non-adjuvant group without intravenous lignocaine. Yes - There is a plan to make this available What will be shared: Data collected included the Primary variables ie heart rate, systolic and diastolic blood pressure, and oxygen saturation 5 minutes post-intubation and 15 minutes into the procedure and median pain scores 1-hour post-extubation in the recovery on standardized Visual Analog Scale When: After approval from the primary author To whom: Public Conditions: Study purpose Where to obtain: the data would be available via email after contacting primary author ,email address is xaheertiwana@gmail.com How to obtain: An email would be sent to the primary author for data sharing request and once approved a link would be given to download the data.All this process would require around 7 days Comments: This study needs furher research on a large scale