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IRCT20230816059159N1 IRCT 2023-10-01 Hamedan University of Medical Sciences combined effect of dexmedetomidine and tranexamic acid in nasal surgery. Investigating the combined effect of dexmedetomidine and tranexamic acid on bleeding and surgeon satisfaction in nasal surgery. 2023-09-23 anticipated 102 Complete https://irct.ir/trial/72099 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: The people under study will be assigned to three intervention groups using the random number generation software. In this way, first, a random table is designed using Microsoft Excel software for the number of samples (102 samples). Numbers 1 to 34 are assigned to the tranexamic acid group, numbers 35 to 68 to the dexmethomedin group, and numbers 69 to 102 to the combined group. Patients are divided into groups in the order they enter the study using a random table. study, Blinding description: Medications are prepared in uniform syringes by the researcher and provided to the clinical caregiver. The clinical caregiver does not know which patient is receiving which drug. The evaluator also does not know which insurance company received which medicine. N/A Bleeding rate in nasal candidate patients. Intervention 1: Combined injection of dexmethomadine (Made by Arang drug therapy Pharmaceutical Company) and ternaxamic acid (Made by Caspian Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery. after the start of general anesthesia, tranexamic acid will prescribe at a dose of 10 mg per kilogram of body weight at a rate of 100 mg per minute. prevention of bleeding in patients who are candidates for nose surgery, dexmedetomidine will prescribe 0.1 micrograms per kilogram of body weight within 10 minutes and then 0.5 micrograms per kilogram of body weight is prescribed within an hour. These drugs are prescribed intravenously. Intervention 2: Injection of dexmedetomidine (Made by Arang drug therapy Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery, dexmedetomidine will prescribe 0.1 micrograms per kilogram of body weight within 10 minutes and then 0.5 micrograms per kilogram of body weight is prescribed within an hour. and during the surgery, this drug is injected intravenously. the patient's bleeding rate and the surgeon's satisfaction are checked. Intervention 3: Injection of ternaxamic acid (Made by Caspian Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery. At the beginning of the surgery, this drug is injected intravenously to the patient in one step, after the start of general anesthesia, tranexamic acid will prescribe at a dose of 10 mg per kilogram of body weight at a rate of 100 mg per minute. and during the surgery, the patient's bleeding rate and the surgeon's satisfaction are checked. Yes - There is a plan to make this available What will be shared: This information is made available after de-identifying individuals and includes information that reports the main outcomes of the plan. When: Access starts from 2031 To whom: The access of anesthesia department instructors is allowed Conditions: The use of data in the way of patient control is unimpeded, its use in the context of review studies is allowed. The data can be used in review studies. In this field, university professors and educational researchers can receive documents by presenting them. Where to obtain: You can access the data by referring to Hamedan University of Medical Sciences, Faculty of Paramedicine, Department of Intelligence, Room 4 or by sending an email to the mentioned address. bk13472000@yahoo.com How to obtain: By sending an email to Behrouz karkhanei and stating the reason for the request, he can use or access the data with an acceptable and effective reason for the education and care of patients. Comments:
public Behroz Karkhanei
Shahid Fahmida St, Hamadan University of Medical Sciences
Hamedan Iran (Islamic Republic of) 6517838667 008138381014 bk13472000@yahoo.com Hamedan University of Medical Sciences scientific Behroz Karkhanei
Shahid Fahmida St, Hamadan University of Medical Sciences
Hamedan Iran (Islamic Republic of) 6517838765 +98 81 3838 1014 bk13472000@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) The patient is a candidate for nasal surgery The patient must be at least 18 years old The patient has informed consent 18 years no limit Both The patient has a history of heart disease The patient has a history of seizures The patient has a history of hypertension Prevention Prevention Prevention Combined injection of dexmethomadine (Made by Arang drug therapy Pharmaceutical Company) and ternaxamic acid (Made by Caspian Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery. after the start of general anesthesia, tranexamic acid will prescribe at a dose of 10 mg per kilogram of body weight at a rate of 100 mg per minute. prevention of bleeding in patients who are candidates for nose surgery, dexmedetomidine will prescribe 0.1 micrograms per kilogram of body weight within 10 minutes and then 0.5 micrograms per kilogram of body weight is prescribed within an hour. These drugs are prescribed intravenously. Injection of dexmedetomidine (Made by Arang drug therapy Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery, dexmedetomidine will prescribe 0.1 micrograms per kilogram of body weight within 10 minutes and then 0.5 micrograms per kilogram of body weight is prescribed within an hour. and during the surgery, this drug is injected intravenously. the patient's bleeding rate and the surgeon's satisfaction are checked. Injection of ternaxamic acid (Made by Caspian Pharmaceutical Company) in the prevention of bleeding in patients who are candidates for nose surgery. At the beginning of the surgery, this drug is injected intravenously to the patient in one step, after the start of general anesthesia, tranexamic acid will prescribe at a dose of 10 mg per kilogram of body weight at a rate of 100 mg per minute. and during the surgery, the patient's bleeding rate and the surgeon's satisfaction are checked. Surgery bleeding. Timepoint: Bleeding measurement time: before drug injection, after drug injection every 15 minutes until the end of surgery. Method of measurement: Volume of blood suctioned in cubic centimeters. Surgeon satisfaction. Timepoint: before drug injection, after drug injection every 15 minutes until the end of surgery. Method of measurement: The surgeon's satisfaction is evaluated based on a four-point classification. The patient's blood pressure. Timepoint: Every 15 minutes after drug injection until the end of surgery. Method of measurement: sphygmomanometer. Hamedan University of Medical Sciences Approved 2023-05-24 Ethics committee of Hamedan University of Medical Sciences Hamedan University of Medical Sciences, Shahid Fahmideh St, Hamedan Hamedan Hamadan Iran (Islamic Republic of)