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IRCT20230721058875N1 IRCT 2023-09-14 Shahid Beheshti University The effect of acute oral ketone supplementation on the response of some appetite-related peptides to one-bout of sprint intermittent exercise in overweight men The effect of acute oral ketone supplementation on the response of some appetite-related peptides to one-bout of sprint intermittent exercise in overweight men 2023-09-24 anticipated 16 Complete https://irct.ir/trial/72057 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Supportive, Randomization description: After initial evaluations, participants will be randomly allocated into two homogeneous groups (Groups A and B) based on body mass index, maximum oxygen consumption, and aerobic power (Wingate). This randomization process will be carried out using IBM SPSS statistical software through simple randomization. The allocation will be done individually by a third party, ensuring that each participant is assigned to either Group A or Group B to prevent bias in group assignments, Blinding description: Using edible flavorings, food supplement beverages, or glucose placebo beverages, identical in terms of volume, calories, taste, and smell, will be prepared by a third party. These solutions will be dissolved in three hundred milliliters of water and provided to the participants in identical opaque cups. Both the participants and the researchers responsible for data collection and evaluation will not know the order of consumption of the food supplement beverage or glucose placebo beverage. N/A Overweight. Intervention 1: Intervention group: The intervention involves consuming a single serving of ketone salt (KETO CaNa), a dietary supplement produced by KETO SPORTS in the United States. Each serving weighs 19 grams and contains 11.7 grams of beta-hydroxybutyrate, 1.1 grams of calcium, 1.3 grams of sodium, and 55 calories. It will be provided to the participants as a solution dissolved in 300 milliliters of water. Intervention 2: Control group: The control group will consume an isocaloric and isovolume placebo consisting of oral glucose and flavoring, dissolved in 300 milliliters of water. Yes - There is a plan to make this available What will be shared: All data obtained from this study will be statistically analyzed, and relevant conclusions will be drawn to form a research article. After undergoing peer review, the article will be published in a scientific journal. The personal information and details of the participants will not be disclosed in accordance with ethical principles. When: after the results are published in a scientific article, the study data will be accessible. This means that the collected data, along with the corresponding results and conclusions, will be made available for reference and utilization by other researchers and interested individuals. To whom: Those who have permission to access data and documents include participants in the study, members of the research team, interested persons, and relevant officials. Of course, access to data must be done in compliance with ethical principles, privacy, and relevant laws. Conditions: Data and documentation will be used to provide scientific information and evidence for further research, and statistical analysis, confirm or reject hypotheses, develop new theories, evaluate and analyze previous results, and support related decisions in various fields. Where to obtain: The data will be readily accessible by simply visiting the website of the scientific journal publishing the research article. How to obtain: The data will be readily accessible by simply visiting the website of the scientific journal publishing the research article. Comments:
public Alireza Esmailiyan
No.8, 6th Farhangian alley, Farhangian street, 3th Phase of Andisheh city, Shahriar
Andisheh city Iran (Islamic Republic of) 33547819580 +98 21 6557 6309 a.esmailiyan.sbu.ac.ir@gmail.com Shahid Beheshti University scientific Alireza Esmailiyan
No.8, 6th Farhangian alley, Farhangian street, 3th Phase of Andisheh city, Shahriar
Andisheh city Iran (Islamic Republic of) 33547819580 +98 21 6557 6309 a.esmailiyan.sbu.ac.ir@gmail.com Shahid Beheshti University Iran (Islamic Republic of) Being a male Being 18 to 35 years old Having BMI between 25 to 30 18 years 35 years Male Having a history of any kind of injury Being a regular smoker Diagnosed with chronic dieses Followed a ketogenic diet in the past six months E66 Overweight and obesity N/A Placebo Intervention group: The intervention involves consuming a single serving of ketone salt (KETO CaNa), a dietary supplement produced by KETO SPORTS in the United States. Each serving weighs 19 grams and contains 11.7 grams of beta-hydroxybutyrate, 1.1 grams of calcium, 1.3 grams of sodium, and 55 calories. It will be provided to the participants as a solution dissolved in 300 milliliters of water. Control group: The control group will consume an isocaloric and isovolume placebo consisting of oral glucose and flavoring, dissolved in 300 milliliters of water. The appetite rate. Timepoint: The appetite rate will be evaluated just before consuming the beverage and once every thirty minutes for two hours. Method of measurement: The appetite rate will be measured using a visual analog scale. The calorie intake. Timepoint: The calorie intake in a meal going to be evaluated two hours after consuming the beverage. Method of measurement: The number of calories consumed will be calculated by weighing the amount of food in the container before and after consumption using a digital scale. The blood ghrelin level. Timepoint: The blood ghrelin level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood ghrelin level will be checked using Enzyme-Linked Immunosorbent Assay (ELISA) kits. The blood beta-hydroxybutyrate level. Timepoint: The blood beta-hydroxybutyrate level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood beta-hydroxybutyrate levels will be checked using biochemical kits. The blood insulin level. Timepoint: The blood insulin level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood insulin level will be checked using Enzyme-Linked Immunosorbent Assay (ELISA) kits. The blood leptin level. Timepoint: The blood leptin level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood leptin level will be checked using Enzyme-Linked Immunosorbent Assay (ELISA) kits. The blood glucose level. Timepoint: The blood glucose level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood glucose level will be checked using biochemical kits. The blood lactate level. Timepoint: The blood lactate level will be measured right before consuming the drink, one hour, and two hours after consuming it. Method of measurement: The blood lactate level will be checked using biochemical kits. self-fund Approved 2023-05-29 Research Ethics Committees of Shahid Beheshti University Shahid Beheshti University, Shahid Shahriari Square, Evin, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)