IRCT20230719058853N1 IRCT 2023-08-12 Vice-Chancellery for Research Hormozgan University of Medical Sciences The effect of magnesium sulfate on the heart and respiration of multiple trauma patients under mechanical ventilation The effect of magnesium sulfate on hemodynamic and respiratory parameters of multiple trauma patients under mechanical ventilation 2023-08-23 anticipated 104 Complete https://irct.ir/trial/71461 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be randomized into two groups using simple randomization with individuals as the unit of randomization and a randomization table produced by the Random Allocation software. An individual uninvolved in the study will write A or B on a card and put it in an opaque envelope. Then the associated number in the randomization table will be written on the back of the envelope. One envelope will be allocated to each patient in order of entrance to the study. Allocation concealment will be done using opaque envelopes, Blinding description: The individual responsible for the assessment of hemodynamic and respiratory parameters will be unaware of patient grouping, while given the nature of the intervention and that there is no placebo, the patient and those related to the patient will not be blinded. Therefore, the study will be single-blind with blinding the assessor. 3 Multiple trauma. Intervention 1: Intervention group: 2 g magnesium sulfate 20% (Shahid Ghazi Co., Tabriz, Iran) in daily serum within 24 hours. Intervention 2: Control group: Only daily serum within the first 24 hours. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.