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IRCT20230713058771N2 IRCT 2023-09-26 Islamic International Dental Hospital Effect of Ibuprofen and Ibuprofen/Dexamethasone Infiltration on Post- Operative Pain in Single Visit Endodontics Effect of Ibuprofen and Ibuprofen/Dexamethasone Infiltration on Post- Operative Pain in Single Visit Endodontics 2023-08-10 anticipated 90 Complete https://irct.ir/trial/71324 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: After proper history taking , investigations and formal consent. Subject was considered in one of our two groups by random allocation (lottery method). In this method each subject was asked to pick a sealed envelope out of the total 90. Each sealed envelope marked which group the subject will be put in. This was concealed from the subject, Blinding description: In Group A, after RCT, single shot local infiltration of 0.5 mg dexamethasone will given in periapical area. In Group B, after RCT local infiltration single shot of placebo(saline) 0.5 mg will be given at periapical area. ( similar delivery method for both groups)Both patient groups were prescribed ibuprofen 400mg three times a day. 2 non vital asymptomatic teeth with necrotic pulp that require endodontic treatment. Intervention 1: Intervention group: group A ibuprofen/dexamethasone infiltration. for this group all participants were given a single infiltration of 0.5 mg dexamethasone at the periapical tissue region. After the completion of root canal therapy. Intervention 2: Control group: group B. for this group of participants a single infiltration of 0.5 mg of normal saline ( placebo) was given at the periapical region after completion of root canal therapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information as for now
public Dr. ABID HUSSAIN
St. 41 7th Ave, G-7/4 G 7/4 G-7, Islamabad, Islamabad Capital Territory
ISLAMABAD Pakistan P34H+5Q9 +92 51 8108795 qazii.abid@hotmail.com Islamic International Dental Hospital scientific Dr. Asim Qureshi
Riaz house hill street opposite hotel one
Abbottabad Pakistan 224400 +92 992 406585 asimovtm@gmail.com Ayub medical & dental college Pakistan Patients of both genders aged 16-45 years with non-vital asymptomatic maxillary single rooted tooth with necrotic pulp. 16 years 45 years Both • Teeth having extensive intra canal calcification. • Teeth with incompletely formed apices • Teeth requiring retreatment • Taking analgesics, anti-inflammatory or tri-cyclic anti-depressants • Allergy to endodontic medication • Teeth with grade II or III mobility (more than 2 mm) Treatment - Drugs Placebo Intervention group: group A ibuprofen/dexamethasone infiltration. for this group all participants were given a single infiltration of 0.5 mg dexamethasone at the periapical tissue region. After the completion of root canal therapy Control group: group B. for this group of participants a single infiltration of 0.5 mg of normal saline ( placebo) was given at the periapical region after completion of root canal therapy Post operative pain. Timepoint: 24, 48, 72 hours after procedure. Method of measurement: visual analog scale. Islamic International Dental Hospital Approved 2023-08-04 The ethical committee at Islamic International Dental Hospital 7th avenue G7/4 , Islamabad Islamabad Federal capital Pakistan