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IRCT201402266709N15 IRCT 2014-06-14 Research deputy of Tabriz University of Medical Sciences The effect of compound oral contraceptives tablets on lipid and carbohydrate metabolism in overweight and obese women Comparing the effect of second and third generation of compound oral contraceptives on lipid and carbohydrate metabolism in overweight and obese women: a randomized clinical controlled trial 2014-05-22 anticipated 137 Complete https://irct.ir/trial/7128 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 2-3 Effect of oral contraception tablets on metabolism. Intervention 1: Intervention group: tablet of contraceptive DE with trade name of Marolin made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Desogestrel, one pill daily for first 21 days of each cycle through three cycles. Intervention 2: Control group: tablet of contraceptive LD with trade name of Ovocept LD made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Levonorgestrel, one oral pill daily for first 21 days of each cycle through three cycles.
public Samira Pourzeinali Beilankooh
Faculty of Nursing and Midwifery, South Shariati Street, Tabriz
Tabriz Iran (Islamic Republic of) 5177854616 +98 41 1447 4467 pourzeinalis@yahoo.com Tabriz University of Medical Sciences scientific Mahnaz Shahnazi
Faculty of Nursing and Midwifery, South Shariati Street, Tabriz
Tabriz Iran (Islamic Republic of) 51745347 +98 41 1479 6770 mshahnazi@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: married women; having regular, spontaneous menstrual cycles varying from 21 to 35 days; body mass index between 25 and 34.9 kilograms per square meter; fasting blood glucose lower than 126 milligrams per deciliter; blood glucose after 2-hour glucose tolerance test lower than 200 milligrams per deciliter; low density lipoprotein lower than 160 milligrams per deciliter; triglycerides lower than 250 milligrams per deciliter; having a desire to participate in the study Exclusion criteria: having absolute and relative contraindications of combined oral contraceptives; using hormonal contraceptive methods during the last 3 months; taking lipid lowering drugs such as lovastatin, Gemfibrozil, Atorvastatin, Cholestyramine, etc; having thyroid and renal diseases 18 years 40 years Female Z30.4 Surveillance of contraceptive drugs Prevention Prevention Intervention group: tablet of contraceptive DE with trade name of Marolin made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Desogestrel, one pill daily for first 21 days of each cycle through three cycles Control group: tablet of contraceptive LD with trade name of Ovocept LD made by Aburaihan Pharmaceutical Company in Tehran, containing 30 micrograms Ethinyl Estradiol and 150 micrograms Levonorgestrel, one oral pill daily for first 21 days of each cycle through three cycles Fasting blood glucose. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. Total cholesterol. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. Low density lipoprotein. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. High density lipoprotein. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. Blood glucose after 2-hour 75 gram oral glucose tolerance test. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. Triglycerides. Timepoint: Before the intervention and three months after intervention. Method of measurement: Spectrophotometric technique. Research deputy of Tabriz University of Medical Sciences Approved 2014-04-28 Ethics committee of Tabriz university of Medical Sciences Research department, third floor, central construction number 2, Tabriz University of Medical Sciences, Golgasht Street, Azadi Avenue, Tabriz Tabriz Iran (Islamic Republic of)