IRCT20121228011912N7 IRCT 2023-10-21 Mashhad University of Medical Sciences Comparison of the effectiveness , TENS, embedding, acupuncture and drug therapy . Comparison of the effectiveness of three treatment methods, TENS, embedding, acupuncture and drug therapy on the level of interleukin 6 and knee osteoarthritis pain. 2023-09-23 anticipated 72 Complete https://irct.ir/trial/71279 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using the online site https://www.sealedenvelope.com random allocation of three classes are placed in a.b.c groups. Randomization based on block randomization will be done with blocks of 4 and 6. The prepared blocks will be placed in envelopes. One of the envelopes will be randomly selected according to the order of patients' arrival, and patients will be assigned to groups based on the obtained blocks. 3 Osteoartritis knee. Intervention 1: Intervention group: Embedding with cut-gut thread in 6 points in a sterile way.The duration of treatment is 8 weeks. Intervention 2: Intervention group: 4 times a week and each time for 30 minutes, they are subjected to TENS ligh frequency by the med device with a frequency of 50-100 Hz by the physiotherapist.The duration of treatment is 8 weeks. Intervention 3: Control group: They are treated with ibuprofen at a dose of 400 mg twice a day at home. The duration of treatment is 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no