IRCT20230318057752N2 IRCT 2023-07-31 Fasa University of Medical Sciences Investigating the effect of caffeine on cognitive and motor responses Effects of brushing with caffeinated toothpaste on cognitive and motor responses of the central nervous system: A pilot study 2023-08-23 anticipated 75 Complete https://irct.ir/trial/71213 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: The randomization of people is done based on the permutation of five random blocks, and the random sequence based on this method will be done by lottery using a table of random numbers, Blinding description: Blocking and allocation sequence for concealment will be done by a person not involved in the research. The shape and packaging of the capsules and toothpaste will be the same so that the researchers and participants will not be aware of the package (one capsule and one toothpaste) of each person. Only the person responsible for packaging the drugs will know the numbers of the respective envelopes, and none of the researchers or participants will know the contents of the package that each person receives. Packages will be placed in A, B, C, D and E envelopes by a person as a coder. Patients will not be aware of the assignment of codes to package envelopes, and the researchers who will provide the packages to the people at the place of implementation of the plan will not be aware of the contents of the packages and the allocation of people to five groups. 3 Cognitive and motor responses of the central nervous system. Intervention 1: Intervention group: The group receiving placebo capsule and toothbrush with 100mg caffeinated toothpaste for 2 minutes. Intervention 2: Intervention group: The group receiving placebo capsule and toothbrush with 100mg caffeinated toothpaste for 3 minutes. Intervention 3: Intervention group: The group receiving placebo capsule and toothbrush with 100mg caffeinated toothpaste for 4 minutes. Intervention 4: Control group: The group receiving 100mg caffeine capsule and toothbrush with regular toothpaste for 2 minutes. Intervention 5: Control group: The group receiving placebo capsule and toothbrush with normal toothpaste for 2 minutes. Yes - There is a plan to make this available What will be shared: Demographic information and clinical trial results When: 3 months after the publication of the article, it will be possible to access the data. To whom: Researchers in all universities of medical sciences Conditions: Researchers can submit their request to the Vice-Chancellor of Research and Technology and the Ethics Committee of Fasa University of Medical Sciences, and if they agree, the data will be provided to them. Where to obtain: Fasa University of Medical Sciences, Vice President of Research and Technology How to obtain: Approval of the Research and Technology Vice-Chancellor and Ethics Committee of Fasa University of Medical Sciences Comments: