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IRCT20230702058644N1 IRCT 2023-08-12 Tabriz University of Medical Sciences Comparison of patients with poor ovarian response included in the antagonist cycle during standard, dual and triple triggering in IVF outcomes Comparison of patients with poor ovarian response included in the antagonist cycle during standard, dual and triple triggering in IVF outcomes 2023-07-11 anticipated 108 Complete https://irct.ir/trial/71198 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Comparison of patients with poor ovarian response included in the antagonist cycle during standard, dual and triple triggering in IVF outcomes, Randomization description: The participants will be allocated to each study group by the balanced block randomization technique. The number of blocks and the size of each block are 36 and 3, respectively (َA, B, and C). The order of study groups in each block will determine the order of allocations. N/A Infertility. Intervention 1: Control group: Standard triggering via the injection of human gonadotropic hormone (hCG). Intervention 2: Intervention group 1: dual triggering via hCG and Decapeptyl. Intervention 3: Intervention group 2: triple triggering via administration of hCG, Decapeptyl, and menotropin. Yes - There is a plan to make this available What will be shared: all collected deidentified IPD When: Our data can be potentially available on October 2023. To whom: People working in academic institutions Conditions: None Where to obtain: email address: zohrehmohammadi98@gmail.com How to obtain: Sending an email to the mentioned address and sending an identity proof that reveals the hiring academic institute is sufficient for us to share the data. Comments:
public Aliyeh Ghasemzadeh
Central Building of Tabriz University of Medical Sciences, Golgasht Street, Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5138665793 +98 41 3177 1041 alghasemzadeh@yahoo.co.uk Tabriz University of Medical Sciences scientific Aliyeh Ghasemzadeh
Central Building of Tabriz University of Medical Sciences, Golgasht Street, Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5138665793 +98 41 3177 1041 alghasemzadeh@yahoo.co.uk Tabriz University of Medical Sciences Iran (Islamic Republic of) informed consent to participate in the study Age between 24-42 years old Body mass index of 19-27 The presence of POR (AFCI <7, AMH <1.5) Eligibility of the patient for IVF The absence of uterine abnormalities 24 years 42 years Female Hypothalamic dysfunctions in the patient diabetes mellitus liver diseases heart diseases renal diseases epilepsy metabolic disorders N97 infertilefertility Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: Standard triggering via the injection of human gonadotropic hormone (hCG) Intervention group 1: dual triggering via hCG and Decapeptyl Intervention group 2: triple triggering via administration of hCG, Decapeptyl, and menotropin The number of good quality embryos. Timepoint: 3 days after fertilization. Method of measurement: High-quality cleavage stage embryos will have six cells or greater on day 3 and less than 10% fragmentation and symmetric blastomeres, according to the Istanbul consensus workshop. Number of retrieved oocytes. Timepoint: 36 hours after triggering. Method of measurement: All oocyte retrievals will be performed under transvaginal ultrasound guidance and will be counted using light microscopy. The number of mature oocytes. Timepoint: 36 hours after triggering. Method of measurement: All oocyte retrievals will be performed under transvaginal ultrasound guidance and the number of mature oocytes will be counted using light microscopy. The number of clinical pregnancies. Timepoint: the presence of gestation sac two weeks after a positive hCG blood test. Method of measurement: ultrasound scan. Implantation rate. Timepoint: at 6–7 weeks of pregnancy. Method of measurement: Implantation rate is calculated from the number of gestational sacs with a visible fetal heart on ultrasound scan divided by the total number of transferred embryos. Tabriz University of Medical Sciences Approved 2023-07-11 Ethics committee of Tabriz University of Medical Sciences Women's Reproductive Health Research Center, A lzahra Educational Hospital, Baghshomal square, South Artesh street, Tabriz, Iran Tabriz East Azarbaijan Iran (Islamic Republic of)