]>
IRCT20230622058557N2 IRCT 2023-07-04 Armed Forces Institute of Dentistry Effect of buffered anesthetics in odontogenic infections Comparison of buffered with standard local anesthetics in odontogenic infections: a randomized controlled trial 2019-03-11 anticipated 70 Complete https://irct.ir/trial/70907 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization was performed using a sealed envelope with a computer-generated random allocation for each patient. According to the this, patients were randomly divided to receive either be in the Buffered Group (A) or Non Buffered Group (B), Blinding description: Double-blind fashion technique was used in which the patient is unaware of the type of anesthetic being administered to them , buffered or standard and the Doctor administering the local anesthesia doesn't know if the cartridge has been buffered or not. It was prepared by another researcher and handed to the doctor administering the injection. 4 Condition 1: Odontogenic Infection: Defined as inflammation originating within a tooth or closely related to the surrounding structures presenting as periapical inflammation in the form of acute periapical periodontitis or a periapical abscess with or without extensions into adjacent facial planes. Condition 2: Odontogenic Infection: Defined as inflammation originating within a tooth or closely related to the surrounding structures presenting as periapical inflammation in the form of acute periapical periodontitis or a periapical abscess with or without extensions into adjacent facial planes. Intervention 1: Intervention group: Group A. This group received buffered local anesthesia by adding 0.18 ml of 8.4 percent sodium bicarbonate solution to 1.8ml 2 % Lignocaine with 1:100,000 adrenaline cartridge immediately before injecting. Intervention 2: Intervention group: Group B. This group will receive standard 2 % Lignocaine with 1:100,000 adrenaline cartridge that has not been buffered. No - There is not a plan to make this available Justification or reason for not sharing IPD is It is the organization's policy to not share IPD
public Syeda Mahnoor Fatima
AFID,CMH, Rawalpindi
Rawalpindi Pakistan 46000 +92 335 5508126 mahnooorbukhari@gmai.com Armed Forces Institute of Dentistry affiliated with National University of Medical Sciences scientific Zahra Saeed
CMH, Lahore
Lahore Pakistan 54810 +92 343 9853049 zahra.saeed15@gmail.com Combined Military Hospital Pakistan Patient between 18 to 70 years that have Odontogenic maxillofacial infection surrounding any tooth. Lack of sensitivity to local anesthetics Patients having acute abscess of any tooth Patients having acute periapical periodontitis leading to granuloma formation Patients having physical status 1 and 2 according to American Society of Anesthesiologists(ASA) classification 18 years 70 years Both Patients with systemic diseases for which injections of lignocaine with adrenaline are contraindicated will be excluded from the study Anesthesia allergy or drug abuse history K04.7 K04.4 Periapical abscess without sinus Acute apical periodontitis of pulpal origin Treatment - Drugs Treatment - Drugs Intervention group: Group A. This group received buffered local anesthesia by adding 0.18 ml of 8.4 percent sodium bicarbonate solution to 1.8ml 2 % Lignocaine with 1:100,000 adrenaline cartridge immediately before injecting. Intervention group: Group B. This group will receive standard 2 % Lignocaine with 1:100,000 adrenaline cartridge that has not been buffered. Pain Assessment: Pain will be determined by the patient before and after injection using VAS Pain score. It is a 10 cm long scale with 0 marking indicating no pain to 10 marking as worst pain possible. Timepoint: Before and immediately after local anesthetic injection. Method of measurement: Visual Analog Pain Score. Efficacy of Anesthesia: Determined by the onset of anesthesia i.e. the first feeling of numbness in the region of the teeth anaesthetized checked by inserting straight probe in the gingival sulcus of the involved region. Timepoint: Immediately after injection is administered with 30 seconds intervals . Method of measurement: Seconds. Armed Forces Institute of Dentistry Approved 2020-03-09 Ethics Committee- Armed Forces Institute of Dentistry AFID, CMH, Rawalpindi Rawalpindi Punjab Pakistan