IRCT20210222050463N2 IRCT 2023-06-26 Ahvaz University of Medical Sciences Comparison of the effects of melatonin, vitamin C and oral clonidine on the patient's hemodynamic response during anesthesia and afterwards to pain in septorhinoplasty surgery. Comparison of the Effect of Oral Melatonin, Vitamin C and Clonidine on the Hemodynamic Response to Endotracheal Intubation, Anesthetic Requirements and Pain after Septorhinoplasty 2023-08-23 anticipated 120 Complete https://irct.ir/trial/70843 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: . Using a table of random numbers generated by the computer, eligible patients will be randomly divided into three groups: melatonin (M group), vitamin C (C group) and clonidine (Cl group) and allocation concealment using envelopes. sealed matte will be done. Both the patient and the researcher will be unaware of the type of drug. The patients in the melatonin group received two tablets (3 mg each), the patients in the vitamin C group received two tablets (1 g each), and the patients in the clonidine group also received two tablets (0.1 mg each) 120 minutes before induction of anesthesia. will do The study drugs in all three groups will be the same in terms of size and color and will be given to the patient by the nursing staff in the ward. 3 Determining the effect of oral melatonin, vitamin C and clonidine on the hemodynamic response to laryngoscopy and endotracheal intubation, the need for anesthetics and pain after septorhinoplasty.. Intervention group:. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available