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IRCT20230621058552N2 IRCT 2023-07-13 Esfahan University of Medical Sciences Comparing collagen superabsorbent powder containing silver nanoparticles 15 ppm and 1% silver sulfadiazine ointment A comparative study of the therapeutic effect of collagen superabsorbent powder containing silver nanoparticles 15 ppm and 1% silver sulfadiazine ointment on the healing of bedsore. 2023-08-06 anticipated 68 Complete https://irct.ir/trial/70823 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: They are divided into two intervention and comparison groups through the table of random numbers. These tables have random numbers in both row and column directions, which usually reach 99 rows and columns, and the numbers of the rows and columns are in blocks of five digits next to each other and in a separated form to facilitate its use. Then we find out the exact number of people in the community and give them a code or machine gun number respectively. To select sample people from the table, we randomly start from a point of the table (by closing the eyes and placing a finger or the tip of the pen on the table) in the direction of the row or column. The chosen small number is actually the code of an individual from the community that is chosen as a sample. This work continues until a small number can be selected for the number of sample people. After the sample volume is complete, the sampling work ends. 3 Bed Sore. Intervention 1: Intervention group: After washing the wound with 0.9% sterile saline, the wound is placed in the open air for 5 minutes so that its surface is completely dry, then a few puffs of Nivasha nano silver spray (with a concentration of 15 ppm and health code 9655068437941620, manufactured by Nano Alvand Arad Company) is applied on the surface of the wounds to sterilize the surface of the wounds. After that, collagen superabsorbent powder containing silver nanoparticles (with a concentration of 15 ppm, manufactured by Nano Alvand Arad company) is poured on the wounds and a layer of Vaseline and sterile gauze is placed on the wounds and bandaged. The wound dressing is changed every 48 hours until the wound heals completely. Intervention 2: Control group: After washing the wound with 0.9% sterile saline, the wound is placed in the open air for 5 minutes so that its surface is completely dry, then a few puffs of Nivasha nano silver spray (with a concentration of 15 ppm and health code 9655068437941620, manufactured by Nano Alvand Arad Company) is applied on the surface of the wounds to sterilize the surface of the wounds. After that, 1% silver sulfadiazine ointment (with the trade name Flamexin, manufactured by Emad Darman Pars Pharmaceutical Company) is used, and a layer of Vaseline and sterile gauze is placed on the wounds and bandaged. Wound dressings are changed daily until the wound heals completely. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Maryam Aghaei
Sedigheh Tahereh hospital . Khoram Street. Jomhori Square.
Isfahan Iran (Islamic Republic of) 81876-98191 +98 31 3339 0100 maryam.aghaei2008@gmai.com Esfahan University of Medical Sciences scientific Dr. Zabihollah Shahmoradi
Leishmaniasis And Skin Diseases Research Center, Sedighe And Tahereh Clinic, Khoram Street, Jomhoori Square.
Isfahan Iran (Islamic Republic of) 81876-98191 +98 31 3339 0100 emrc@mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients aged 35-80 years with at least 30-day-old ulcers. The wound should be defined as a cavitary bed wound, Wagner grade 3-4. No local or systemic signs of infection, with normal CRP and leukocyte levels 35 years 80 years Both Treatment - Drugs Treatment - Drugs Intervention group: After washing the wound with 0.9% sterile saline, the wound is placed in the open air for 5 minutes so that its surface is completely dry, then a few puffs of Nivasha nano silver spray (with a concentration of 15 ppm and health code 9655068437941620, manufactured by Nano Alvand Arad Company) is applied on the surface of the wounds to sterilize the surface of the wounds. After that, collagen superabsorbent powder containing silver nanoparticles (with a concentration of 15 ppm, manufactured by Nano Alvand Arad company) is poured on the wounds and a layer of Vaseline and sterile gauze is placed on the wounds and bandaged. The wound dressing is changed every 48 hours until the wound heals completely. Control group: After washing the wound with 0.9% sterile saline, the wound is placed in the open air for 5 minutes so that its surface is completely dry, then a few puffs of Nivasha nano silver spray (with a concentration of 15 ppm and health code 9655068437941620, manufactured by Nano Alvand Arad Company) is applied on the surface of the wounds to sterilize the surface of the wounds. After that, 1% silver sulfadiazine ointment (with the trade name Flamexin, manufactured by Emad Darman Pars Pharmaceutical Company) is used, and a layer of Vaseline and sterile gauze is placed on the wounds and bandaged. Wound dressings are changed daily until the wound heals completely. Frequency distribution of improvement rate in patients treated with collagen superabsorbent powder and silver sulfadiazine ointment. Timepoint: Measurement of the wound surface at the beginning of the study (before the start of the intervention) and every 48 hours after starting the use of collagen superabsorbent powder and silver sulfadiazine ointment. Method of measurement: Using caliper software with a unit of mm. Esfahan University of Medical Sciences Approved 2023-03-14 Ethics committee of Isfahan University of Medical Sciences Hezar jarib Street. Azadai Square, Isfahan. Isfahan Isfehan Iran (Islamic Republic of)